Myotis bat STING attenuates aging-related inflammation in female miceOACSTPCD
Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 years.However,the mechanisms underlying these distinctive traits remain incompletely understood.In our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation.To substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse genome.We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging process.Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in vivo.These results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner.Although the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.
Xi Wang;Jing-Kun Jia;Qi Wang;Jing-Wen Gong;Ang Li;Jia Su;Peng Zhou
Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China University of Chinese Academy of Sciences,Beijing 100000,ChinaWuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China University of Chinese Academy of Sciences,Beijing 100000,ChinaWuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China University of Chinese Academy of Sciences,Beijing 100000,ChinaWuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China State Key Laboratory of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical School,Guangzhou,Guangdong 510005,ChinaWuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China University of Chinese Academy of Sciences,Beijing 100000,ChinaWuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510005,China State Key Laboratory of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical School,Guangzhou,Guangdong 510005,China
生物学
BatSTINGLongevityAging-related inflammationVirus reservoir host
《Zoological Research》 2024 (5)
P.961-971,11
supported by the China Natural Science Foundation for Outstanding Scholars(82325032)Self-Supporting Program of Guangzhou Laboratory(SRPG22-001)。
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