难治性抽动障碍的中医证素及临床特征分析OACSTPCD

Objective To investigate the distribution and clinical characteristics of TCM pattern elements in Tourette syndrome. Methods According to the diagnostic criteria,the cases were divided into two groups:the common TS Group and the refractory TD Group. To compare and analyze the clinical related factors by using chi-square test,to study and analyze the TCM pattern elements of the nature and location of the disease and the grade distribution of the location of the refractory TD disease.Results There were significant differences in age at onset,course of disease,mental stimulation,disease induction,no obvious inducement,lack of father's education,family rearing pattern,parents' anxiety about disease,type and time of taking medicine and comorbidity of ADHD between the two groups. The main symptoms of TCM pattern elements in the two groups were surface,liver,kidney,spleen and lung,and the difference was significant (P<0.05). The main symptoms of the disease were phlegm,hyperactivity of Yang,deficiency of blood,deficiency of Yin,wind,deficiency of Qi,heat and blood heat,and there were significant differences in Phlegm,hyperactivity of Yang,deficiency of Yin,deficiency of qi and blood heat (P<0.05),in the distribution of disease location,liver syndrome elements were mainly in Grade Ⅱ(moderate lesion) and grade Ⅲ(severe lesion),while Yin deficiency syndrome elements were mainly in Grade Ⅱ(moderate lesion) and grade Ⅲ-LRB-severe lesion),grade Ⅲ(severe pathological changes) is the main type of wind-moving syndrome. Conclusions The age of onset,family rearing pattern,time of taking medicine,and comorbidity of ADHD are the risk factors of developing common TS into refractory TD. The syndrome elements of the two groups were mainly located in the liver,the common syndrome elements of TS disease were mainly wind-induced,and the refractory syndrome elements of TS disease were mainly yin-deficiency,which indicated that the nature of the disease changed from excess to deficiency with the development of the disease,and the grade distribution suggested that the liver was the focus of the disease,yin deficiency and wind phlegm is one of the main pathogenesis of the disease.