现代中医临床2024，Vol.31Issue(5)：97-102,6.DOI:10.3969/j.issn.2095-6606.2024.05.022
脑小血管病白质高信号肾虚证的脑网络特征研究
Study on brain network characteristics of kidney deficiency patients with high white matter hyperintensities in cerebral small vessel disease
摘要
Abstract
Objective To explore the characteristics of resting brain network in kidney deficiency pa-tients with high white matter hyperintensities (WMH). Methods Clinical and functional magnetic reso-nance imaging (fMRI) data were collected from patients with WMH and healthy subjects. We analyzed and compared the differences of brain function between the two groups by using regional homogeneity (ReHo). Patients with WMH were divided into kidney deficiency group and non-kidney deficiency group,and independent component analysis (ICA) was used to explore the characteristics of brain net-work. Results Compared with the healthy group,the ReHo value of the WMH groups decreased signifi-cantly in the right precuneus and right supplementary motor area,and increased significantly in the right temporal lobe. The ReHo value of the temporal lobe was positively correlated with HAMD score. ICA a-nalysis showed that the connection between the default mode network and the frontoparietal network in the kidney deficiency group was stronger,while the connection to the auditory network and visual network was weaker in the kidney deficiency group. Conclusion The abnormal functional connections of emo-tional and cognitive brain regions in patients with WMH kidney deficiency syndrome can provide objective reference for the prevention and treatment of these diseases.关键词
白质高信号/局部一致性/独立成分分析/脑网络/中医证候Key words
white matter hyperintensities/regional homogeneity/independent component analysis/brain network/TCM syndrom分类
医药卫生引用本文复制引用
高金阳,林丹,路一坤,张硕,周莹,马丽芳,韩笑,崔方圆..脑小血管病白质高信号肾虚证的脑网络特征研究[J].现代中医临床,2024,31(5):97-102,6.基金项目
国家自然科学基金青年基金项目(No.8200151376) （No.8200151376）
