广东医学2024，Vol.45Issue(9)：1101-1105,5.DOI:10.13820/j.cnki.gdyx.20240833
血清鸢尾素及摄食抑制因子在中枢性性早熟女童诊断中的意义
Diagnostic significance of serum irisin and nesfatin-1 in girls with central precocious puberty
摘要
Abstract
Objective To investigate the expression levels of serum irisin and nesfatin-1 and their clinical diag-nostic value in girls with central precocious puberty(CPP).Methods A total of 74 girls diagnosed with CPP from Janu-ary 2018 to January 2022 at Tangshan Maternal and Child health Care Hospital were included in the CPP group.Sixty girls with isolated premature thelarche(PT)during the same period served as the PT group.Serum levels of irisin and nesfatin-1 were measured using enzyme-linked immunosorbent assay(ELISA).Pearson correlation analysis was used to examine the relationship between serum irisin,nesfatin-1 levels,and clinical data of CPP patients.Multivariate logistic regression was employed to identify factors influencing the occurrence of CPP.Receiver operating characteristic(ROC)curve analy-sis was conducted to assess the diagnostic value of serum irisin and nesfatin-1 for CPP.Results The levels of serum iri-sin,nesfatin-1,body mass index(BMI)standard deviation scores,advanced bone age,basal luteinizing hormone(LH),basal follicle-stimulating hormone(FSH),basal LH/FSH ratio,estradiol 2,ovarian volume,and uterine vol-ume were significantly higher in the CPP group than in the PT group(all P＜0.05).There were significant positive corre-lations between serum irisin,nesfatin-1,and BMI standard deviation scores,advanced bone age,basal LH,basal FSH,basal LH/FSH ratio,estradiol,ovarian volume,and uterine volume in the CPP group(all P＜0.05).Serum irisin and nesfatin-1 were identified as independent risk factors for CPP.The area under the ROC curve(AUC)for the combined detection of serum irisin and nesfatin-1 was 0.927(95％CI:0.891-0.959),which was significantly greater than that for each marker alone[0.839(95％CI:0.799-0.857)for irisin,0.812(95％CI:0.781-0.842)for nesfatin-1](Z=5.183,4.949,both P＜0.001).Conclusion Elevated levels of serum irisin and nesfatin-1 are observed in girls with CPP,and these levels are associated with hormone levels in CPP girls.The combination of serum irisin and nesfatin-1 offers a higher clinical diagnostic value for CPP than either marker alone.关键词
中枢性性早熟/鸢尾素/摄食抑制因子/诊断/女童Key words
central precocious puberty/iridin/nesfatin-1/diagnosis/girls分类
医药卫生引用本文复制引用
焦娇,张雪松,郑新月..血清鸢尾素及摄食抑制因子在中枢性性早熟女童诊断中的意义[J].广东医学,2024,45(9):1101-1105,5.基金项目
河北省医学科学研究课题计划(20231770) （20231770）
