广东医学2024，Vol.45Issue(9)：1211-1215,5.DOI:10.13820/j.cnki.gdyx.20240656
NLRP3炎症小体及相关通路与溃疡性结肠炎的研究进展
Research on NLRP3 inflammasome and related pathways in ulcerative colitis
摘要
Abstract
Ulcerative colitis is a persistent or recurrent chronic non-specific inflammatory disease of the intes-tine,and its etiology and pathogenesis are currently unclear.NLPR3 inflammasome is a type of high molecular protein complex that can initiate inflammatory responses and induce cell pyroptosis in innate immunity.Recent studies have shown that NLRP3 inflammasomes and related pathways,as important components of innate immunity,play an important role in the occurrence and development of ulcerative colitis by activating inflammatory responses and inducing cell pyroptosis.This article reviews the relationship between NLRP3 inflammasome and related pathways and ulcerative colitis,providing reference for subsequent related research.关键词
核苷酸结合寡聚化结构域样受体蛋白3/炎症小体/溃疡性结肠炎/信号通路Key words
nucleotide binding oligomerization domain-like receptor protein 3/inflammasome/ulcerative coli-tis/signal pathway分类
医药卫生引用本文复制引用
蔡碧莲,崔锦珠,覃小华,何晓金,段晓鑫,钟焕英,文亦磊..NLRP3炎症小体及相关通路与溃疡性结肠炎的研究进展[J].广东医学,2024,45(9):1211-1215,5.基金项目
国家自然科学基金项目(82160880) （82160880）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200288) （Z20200288）
