李凤春 1许教雄 2何仁亮 3李辉 1严丽娟 1马玉楠4
作者信息
- 1. 珠海市第三人民医院,广东 珠海 519001
- 2. 中山市黄圃人民医院,广东 中山 528429
- 3. 南方医科大学皮肤病医院,广东 广州 510091
- 4. 南方医科大学公共卫生学院流行病学系,广东 广州 510515
- 折叠
摘要
Abstract
Objective To observe the efficacy of plum-blossom needling combined with tazaro-tene cream and imiquimod cream in the treatment of multiple plantar warts.Methods Sixty pa-tients with multiple plantar warts were randomly divided into the observation group,control groups 1 and 2,20 cases per group.After removal part of warts and thickened stratum corneum with scal-pel,the observation group was treated with plum-blossom needling in combination with tazarotene cream and imiquimod cream.And the control group 1 was treated with fractional CO2 laser in com-bination with tazarotene cream and imiquimod cream,while the control group 2 was treated with tazarotene cream and imiquimod cream alone.Plum-blossom needling and fractional CO2 laser were given once every 10 days for a total of no more than 9 times.All patients were treated for 3 months and adverse reactions were observed during the follow-up period.The clinical efficacy was compared among three groups.The recurrence rates were observed during a 3-month follow-up af-ter the treatment.Results The cure rates in observation group,and control groups 1 and 2 were 94.44％,88.24％and 45.0％,respectively(x2=14.63,P＜0.05).However,there were no significant differences in cure rate,total number of treatment and the duration of treatment between the observation and control group 1(cure rate:Z=-0.61,P＞0.0167,total number of the treatment:Z=-0.37,P＞0.0167,the duration of the treatment:Z=-0.36,P＞0.0167).In contrast,the observation group had higher cure rate(Z=-3.23,P＜0.0167),fewer treat-ments(Z=-2.57,P＜0.0167)and shorter treatment duration(Z=-2.59,P＜0.0167)in comparison to the control group 2.The recurrence rates were comparable among the three groups.No severe adverse reactions were observed in any groups during the treatment.Conclusions Plum-blossom needling combined with tazarotene cream and imiquimod cream displays a compara-ble efficacy to fractional CO2 laser in combination with tazarotene cream and imiquimod cream,but superior to tazarotene cream and imiquimod cream alone,for multiple plantar warts.Plum-blossom needling combined with tazarotene cream and imiquimod cream is a simple and effective regimen for multiple plantar warts.关键词
多发性跖疣/梅花针/点阵激光/他扎罗汀/咪喹莫特Key words
multiple plantar warts/plum-blossom needle/fractional CO2 laser/tazaro-tene/imiquimod
