皮肤性病诊疗学杂志2024，Vol.31Issue(9)：629-633,5.DOI:10.3969/j.issn.1674-8468.2024.09.009
以皮肤结节为首发表现的结节病2例
Two cases of sarcoidosis presenting with skin nodules as the first manifestation
摘要
Abstract
We report two cases of sarcoidosis presenting with skin nodules as the first manifes-tation,without prominent respiratory symptoms.Chest CT showed multiple pulmonary nodules and lymphadenopathy.Case 1,a 47-year-old female,presented with nodules on the elbows and fin-gers.Dermatological examination revealed demarcated,asymptomatic red and skin-colored nodules on the right elbow,and the index finger and the little finger of the left hand,sized 0.3 to 0.9 cm in diameter.Histopathology of the left pinky finger showed normal epidermis and epithelia granulo-ma with fibrous encapsulated naked tubercles in the dermis.Chest CT revealed bronchitis and multiple nodules in the both lungs,mediastinal and hilar lymphadenopathy.The diagnosis was sar-coidosis.Case 2,a 44-year-old female,complained of a 3-month history of nodules on the left lower limb.Dermatological examination showed two dark red and skin-colored nodules,sized 2.0 cm ×2.0 cm and 3.0 cm ×2.0 cm,respectively,on the anterior tibia of the left lower leg.A demarcated asymptomatic skin-colored nodule was observed on the posterior left lower leg.Histo-pathology of the left shin revealed mild epidermal hyperplasia and superficial dermal infiltrates of epithelioid cells and multinucleated giant cells.Chest CT revealed multiple nodules in the lower lobe of the left lung,upper and middle lobes of the right lung,mosaic perfusion of both lungs,a few fibers and calcifications in the middle and lower lobes of the right lung,mediastinal lymphade-nopathy with calcification.Patients was diagnosed with sarcoidosis.Both patients were treated with oral prednisone acetate at 30 mg/d for 2 months,followed by a gradual reduction in glucocorticoid dose.No new rash was found after one-year follow-up.关键词
结节病/胸部CT/组织病理Key words
sarcoidosis/chest computed tomography/histopathology引用本文复制引用
林丽,秦晓明..以皮肤结节为首发表现的结节病2例[J].皮肤性病诊疗学杂志,2024,31(9):629-633,5.基金项目
皖南医学院校级重点科研基金项目(WK2019ZF13) （WK2019ZF13）
皖南医学院第二附属医院"登峰计划"人才科研项目(DFJH2022009) （DFJH2022009）
