皮脂腺衰老的表现及发生机制研究进展OA

Aging in the sebaceous glands typically begins on the sun-exposed areas,character-ized by sebaceous gland hyperplasia and lipid dysbiosis.These changes result in dry and dull skin,alterations in the microbiota,pigmentation,and various skin diseases.Both intrinsic and ex-trinsic factors contribute to this process,causing dilation of sebaceous ducts,reducing lipid secre-tion,promoting gland proliferation,and inducing inflammation.Key downstream mechanisms driv-ing sebaceous gland aging include reactive oxygen species(ROS),autophagy,the Wnt signaling pathway,and mitochondrial dysfunction.Interventions such as antioxidants,probiotics,photother-apy,and exosomes can delay the sebaceous gland aging.This article will discuss the manifesta-tions of the sebaceous gland aging,elucidate its underlying mechanisms,review current research progress,and explore potential countermeasures.