日用化学品科学2024，Vol.47Issue(10)：39-45,7.DOI:10.3969/j.issn.1006-7264.2024.10.007
脂质体促进抗坏血酸四异棕榈酸酯的渗透吸收
Application of liposomes in promoting penetration and absorption of Ascorbyl Tetraisopalmitate
周彪 1袁菊懋 1徐思伟 1陈丽1
作者信息
- 1. 上海科黛生物科技有限公司,上海 201703
- 折叠
摘要
Abstract
Through oil-in-water emulsification,the lecithin-derived liposomes were dispersed in the water phase and the high concentration of ascorbate tetraisopalmitate(Vitamin C tetra-isopalmitate)was dispersed in the oil phase to prepare a certain dosage form of preparation,and to avoiding the stability problems and low drug loading problems caused by liposome encapsulation.The results showed that after emulsification of 10%VCIP with different concentrations of liposomes,the transdermal absorption was enhanced.With the increase of liposome concentration,the permeability of VCIP first increased and then stabilized.The results of anti-H2O2 oxidative damage,promotion of fibroblast proliferation,collagen-related gene expression,anti-melanin test and inhibition of matrix metalloproteinase gene expression showed that emulsified preparations containing liposome had stronger efficacy than those without liposome,and showed a very significant difference when the liposome concentration was≥0.5%.This study has certain guiding significance in the transdermal absorption preparations of cosmetics.关键词
卵磷脂/抗坏血酸四异棕榈酸酯/透皮吸收/成纤维细胞/基因表达Key words
Lecithin/Vitamin C tetra-isopalmitate/transdermal absorption/fibroblast/gene expression分类
化学化工引用本文复制引用
周彪,袁菊懋,徐思伟,陈丽..脂质体促进抗坏血酸四异棕榈酸酯的渗透吸收[J].日用化学品科学,2024,47(10):39-45,7.
