上海针灸杂志2024，Vol.43Issue(10)：1063-1069,7.DOI:10.13460/j.issn.1005-0957.2024.10.1063
针刺联合中药治疗卵巢储备功能减退的疗效观察
Therapeutic observation of acupuncture plus Chinese medicine in treating diminished ovarian reserve
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture plus Bu Shen Jian Pi formula in treating diminished ovarian reserve(DOR).Method A total of 120 patients with DOR of dual deficiency of the spleen and kidney pattern were recruited and divided into an acupuncture group(40 cases),a Chinese medication group(40 cases),and a combined acupuncture-medication group(40 cases)using the random number table method.The acupuncture group only received acupuncture treatment,the Chinese medication group received Bu Shen Jian Pi formula via oral administration,and the combined acupuncture-medication group was offered acupuncture plus Bu Shen Jian Pi formula.Before and after the treatment,the three groups were observed for changes in the serum levels of anti-Müllerian hormone(AMH),follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and FSH/LH.Changes in the symptom and sign score and antral follicle count(AFC)were also observed.The clinical efficacy was compared among the three groups.Result The total effective rate was 90.0%,62.5%,and 60.0%in the combined acupuncture-medication group,Chinese medication group,and acupuncture group,respectively;there was no significant difference in comparing the total effective rate between the Chinese medication and acupuncture groups(P=0.05),and the combined acupuncture-medication group was significantly higher than the other two groups in comparing the total effective rate(P＜0.05).After the intervention,the serum AMH level and AFC increased in all three groups(P＜0.05)and were higher in the combined acupuncture-medication group than in the Chinese medication and acupuncture groups(P＜0.05).The symptom and sign score dropped after the treatment in the three groups(P＜0.05)and was lower in the combined acupuncture-medication group than in the other two groups(P＜0.05).After the treatment,all three groups showed a decreased FSH level(P＜0.05)and an increased E2 level(P＜0.05),and the combined acupuncture-medication group was superior to the other two groups in comparing the levels of FSH and E2(P＜0.05);the LH level was lower in the combined acupuncture-medication group than in the acupuncture group(P＜0.05),and the FSH/LH level was lower in the combined acupuncture-medication group than in the Chinese medication group(P＜0.05).Conclusion Acupuncture plus Bu Shen Jian Pi formula can improve ovarian function in DOR patients,enhancing the follicle number and quality,alleviating symptoms,and regulating sex hormone levels.This combined method can produce more significant efficacy than the two methods used separately.关键词
针刺疗法/针药并用/卵巢储备/不育,女性/脾肾两虚Key words
Acupuncture therapy/Acupuncture medication combined/Ovarian reserve/Infertility,Female/Dual deficiency of the spleen and kidney分类
医药卫生引用本文复制引用
李嘉,杨红,齐聪,沈卫东..针刺联合中药治疗卵巢储备功能减退的疗效观察[J].上海针灸杂志,2024,43(10):1063-1069,7.基金项目
上海市科学技术委员会科技计划项目(21Y11923400) （21Y11923400）
海派中医流派传承创新团队建设项目(2021LPTD-004) （2021LPTD-004）
上海市卫生健康委员会科研项目(202240007) （202240007）
上海中医药大学附属曙光医院"四明临床研究专项"(SGKJLC-202009) （SGKJLC-202009）
第七批全国老中医药专家学术经验继承工作项目 （）
