上海针灸杂志2024，Vol.43Issue(10)：1091-1097,7.DOI:10.13460/j.issn.1005-0957.2024.10.1091
针灸治疗浆细胞性乳腺炎的疗效观察及对JAK2/STAT3信号通路关键蛋白的影响
Efficacy observation of acupuncture-moxibustion in treating plasma cell mastitis and the effects on key proteins of JAK2/STAT3 signaling pathway
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture-moxibustion in treating plasma cell mastitis and the effects on key proteins of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway.Method Ninety-six patients with plasma cell mastitis were randomized into an observation group and a control group,each consisting of 48 cases.The control group was given Methylprednisolone,and the observation group received additional acupuncture and moxibustion treatment based on the intervention for the control group.The clinical efficacy,recurrence,and adverse reactions were compared between the two groups.Before and after the treatment,both groups were observed for breast symptom scores(breast lump diameter,breast lump extent,breast pain,and the skin of the breast),serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),and C-reactive protein(CRP)],serum immune indexes[immunoglobulin G(IgG),immunoglobulin M(IgM),complement 3(C3),and complement 4(C4)],and the levels of key protein levels of the JAK2/STAT3 signaling pathway in the breast tissue fluid[JAK2,phosphorylated JAK2(p-JAK2),STAT3,and phosphorylated STAT3(p-STAT3).Result The total effective rate was 97.9%in the observation group,higher than 75.6%in the control group(P＜0.05);at the 3-month post-treatment follow-up,the relapse rate was 2.2%in the observation group,lower than 26.5%in the control group(P＜0.05).After the treatment,the breast lump diameter,breast lump extent,breast pain,and breast skin scores were lower in the observation group than in the control group(P＜0.05),and the levels of TNF-α,IL-6,IL-8,CRP,IgG,IgM,C3,C4,JAK2,p-JAK2,STAT3,and p-STAT3 in the observation group were lower than those in the control group(P＜0.05).The adverse reaction rate was 31.1%in the control group,higher than 23.4%in the observation group(P＜0.05).Conclusion Acupuncture-moxibustion plus Methylprednisolone can produce more significant clinical efficacy than using Methylprednisolone alone in treating plasma cell mastitis.This combined method can better relieve symptoms such as breast lump and pain and lower recurrence,and the mechanism may be related to regulating key proteins of the JAK2/STAT3 signaling pathway.关键词
针灸疗法/艾条灸/乳腺炎/女性/非受体型酪氨酸蛋白激酶2/信号转导及转录激活蛋白3Key words
Acupuncture-moxibustion/Moxa stick moxibustion/Mastitis/Female/Janus kinase 2/Signal transducer and activator of transcription 3分类
医药卫生引用本文复制引用
赵莉,栗粟..针灸治疗浆细胞性乳腺炎的疗效观察及对JAK2/STAT3信号通路关键蛋白的影响[J].上海针灸杂志,2024,43(10):1091-1097,7.基金项目
河南省中医药科学研究专项课题(2022ZY1081) （2022ZY1081）
