上海针灸杂志2024，Vol.43Issue(10)：1105-1111,7.DOI:10.13460/j.issn.1005-0957.2024.10.1105
基于脑肠轴理论观察针刺治疗卒中后抑郁的临床疗效
Clinical efficacy of acupuncture in treating post-stroke depression based on the brain-gut axis theory
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture in the treatment of post-stroke depression based on the theory of brain-gut axis.Method Seventy-four patients with post-stroke depression were selected and divided into a trial group and a control group according to the random number table method,with 37 cases in each group.Both groups received conventional Western medicine treatment.The control group was treated with Xing Nao Kai Qiao acupuncture,while the trial group was treated with electroacupuncture based on the theory of brain-gut axis in addition to the treatment of the control group.The clinical efficacy of the two groups was compared,and the Chinese medicine main pattern scores,Hamilton depression scale(HAMD)scores,National Institute of Health stroke scale(NIHSS)scores,and activity of daily living(ADL)scores were observed before and after treatment in the two gruops.The changes of serum gastrin(GAS),somatostatin(SS),5-hydroxytryptamin(5-HT),and brain-derived neuotrophyic factor(BDNF)levels were compared between the two groups before and after treatment.Result The total effective rate of depression and Chinese medicine main pattern scores in the trial group were higher than those in the control group(P＜0.05).The Chinese medicine main pattern scores,HAMD score and NIHSS score of both groups were lower than those of the same group before treatment(P＜0.05),and the ADL score was higher than those of the same group before treatment(P＜0.05);the above scores of the trial group were better than those of the control group after treatment(P＜0.05).The serum SS level decreased in both groups after treatment(P＜0.05),and the serum GAS,5-HT and BDNF levels increased(P＜0.05);and the serum SS level of the trial group was lower than that of the control group(P＜0.05),and the serum GAS,5-HT and BDNF levels were higher than those of the control group(P＜0.05)after treatment.Conclusion On the basis of conventional Western medicine treatment,Xing Nao Kai Qiao acupuncture and electroacupuncture therapy based on the theory of brain-gur axis can better alleviate the clinical symptoms of post-stroke depression,improve the neurological function and daily life ability,and improve the clinical efficacy,which may be related to the regulation of serum SS,GAS,5-HT and BDNF levels.关键词
针刺疗法/电针/针药并用/脑梗死/中风/抑郁/脑肠轴Key words
Acupuncture therapy/Electroacupuncture/Acupuncture medication combined/Cerebral infarction/Stroke/Depression/Brain-gut axis分类
医药卫生引用本文复制引用
江娅芬,潘进花,吴江霞,吴丽啸,章连新..基于脑肠轴理论观察针刺治疗卒中后抑郁的临床疗效[J].上海针灸杂志,2024,43(10):1105-1111,7.基金项目
金华市科学技术研究计划项目(2020-4-124) （2020-4-124）
