上海针灸杂志2024，Vol.43Issue(10)：1112-1120,9.DOI:10.13460/j.issn.1005-0957.2024.10.1112
针刺联合中药治疗支气管哮喘急性发作期的疗效观察
Therapeutic efficacy of acupuncture combined with Chinese medicine in the treatment of acute exacerbation of bronchial asthma
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with modified Jun Qi Tang in the treatment of acute exacerbation of bronchial asthma.Method A total of 135 patients with acute exacerbation of bronchial asthma were randomly divided into a Western medicine group,a Chinese medicine group and an acupuncture-Chinese medicine group,with 45 cases in each group.Three groups of patients received basic treatment,the Western medicine group was treated with oral Montelukast sodium tablets,the Chinese medicine group was treated with modified Jun Qi Tang orally,and the acupuncture-Chinese medicine group was treated with acupuncture combined with modified Jun Qi Tang.The asthma control test(ACT)score,Marks-asthma quality of life questionnaire(Marks-AQLQ)score,cough score,CT airway remodeling index[airway wall thickness(AWT),the airway wall thickness(AWT)score,airway wall area(AWA),AWT percentage of airway outer diameter(AWTP),and AWA percentage of total airway cross-sectional area(AWAP)]were compared among the three groups.The changes of inflammatory factors[cysteine leukotrienes(CysLTs),CC motif chemokine receptor 6(CCR6),soluble intercellular adhesion molecule-1(SIAM-1),and nuclear factor-κB(NK-κB)]and T-lymphocyte subsets[regulatory T-cells(Treg),T helper 2 cell(Th2),T helper 17 cell(Th17)and T helper 23 cell(Th23)]levels in sputum and serum before and after treatment were observed in the three groups.The clinical efficacy and the occurrence of adverse reactions were compared among the three groups.Result The total effective rate of the acupuncture-Chinese medicine group was 97.8%,which was higher than that of the Western medicine group(80.0%)and the Chinese medicines group(82.2%),and the differences were statistically significant(P＜0.05).After treatment,the ACT score of the acupuncture-Chinese medicine group was higher than that of the Western medicine group and the Chinese medicine group(P＜0.05),the Marks-AQLQ,daytime cough and nocturnal cough scores were lower than those of the Western medicine group and the Chinese medicine group(P＜0.05),and the levels of AWT,AWA,AWTP and AWAP were lower than those of the Western medicine group and the Chinese medicine group(P＜0.05).After treatment,the levels of CYSLTS,CCR6,sICAM-1,NK-κB,Th2,Th17 and Th23 in sputum and serum of the acupuncture-Chinese medicine group were lower than those in the Western medicine group and the Chinese medicine group(P＜0.05),and the levels of Treg were higher than those in the Western medicine group and the Chinese medicine group(P＜0.05).The incidence of adverse reactions in both the acupuncture-Chinese medicine group and the Chinese medicine group was lower than that in the Western medicine group(P＜0.05).Conclusion On the basis of the basic treatment,acupuncture combined with modified Jun Qi Tang can significantly alleviate the symptoms of shortness of breath and wheezing in patients with acute exacerbation of bronchial asthma,reduce airway remodeling,lower the level of inflammatory factors,enhance the immunity,and the therapeutic effect is better than that of Western medicine treatment alone and Chinese medicine treatment alone.关键词
针刺疗法/针药并用/哮喘/急性期/冷哮/气道重塑/炎性因子Key words
Acupuncture therapy/Acupuncture medication combined/Asthma/Acute stage/Cold wheezing/Airway remodeling/Inflammatory factor分类
医药卫生引用本文复制引用
马方,魏永魁,位亚丽..针刺联合中药治疗支气管哮喘急性发作期的疗效观察[J].上海针灸杂志,2024,43(10):1112-1120,9.基金项目
河南省中医药科学研究专项课题(20-21ZY2206) （20-21ZY2206）
