眼科学报2024，Vol.39Issue(8)：409-415,7.DOI:10.12419/24073102
三维细胞培养在青光眼研究中的应用
Application of three-dimensional culture in the study of glaucoma
摘要
Abstract
Glaucoma is the world's first irreversible blinding eye disease,characterized by degenerative changes in retinal ganglion cells(RGCs),which have a significant impact on the global economy and health.The molecular and biological mechanisms of its pathological changes are still unclear.At present,glaucoma surgery and drug therapy are still limited to controlling the intraocular pressure in the normal range.Three-dimensional culture technology can enable cells to form a certain spatial structure in vitro,which is conducive to cell-cell and cell-environment interactions.Compared with traditional two-dimensional culture,three-dimensional culture technology is closer to the physiological environment of cells in vivo,which is of great significance for the study of pathophysiological changes of diseases and high-throughput drug screening.This review discusses the application of trabecular mesh and three-dimensional culture of retinal cells in the basic research of glaucoma,aiming to provide new ideas for further exploring the pathophysiological mechanism of glaucoma.关键词
青光眼/三维培养/小梁网/视网膜/三维支架Key words
glaucoma/three-dimensional culture/trabecular net/retina/three-dimensional support分类
医药卫生引用本文复制引用
蒋宇凡,车煜彤,杨扬帆..三维细胞培养在青光眼研究中的应用[J].眼科学报,2024,39(8):409-415,7.基金项目
高校基本科研业务费重点项目(23xkjc022).This work was supported by Fundamental Research Funds for the Central Universities,Sun Yat-sen University(23xkjc022). （23xkjc022）
