眼科学报2024，Vol.39Issue(8)：424-430,7.DOI:10.12419/24072304
先天性晶状体脱位的治疗及预后研究进展
Recent advances in research onthe treatment and prognosis of congenital ectopia lentis
摘要
Abstract
Congenital ectopia lentis(CEL)is a rare genetic disorder characterized by the displacement of the lens from its normal anatomical position due to abnormalities in the lens zonular.As the progression of the disease,CEL can lead to high refractive error,even amblyopia,as well as other serious complications such as secondary glaucoma and retinal detachment.Currently,surgical intervention remains the primary method to improve the visual quality and prevent complications in children with CEL.Common surgical options include lens extraction,anterior chamber intraocular lens(IOL)implantation,IOL implantation combined with capsular tension devices,and transcleral fixation of IOL.Each surgical approach has its own characteristics,but there is currently no consensus on the best surgical method.Previous literature has shown that surgery can significantly improve vision in children with CEL;however,due to the growth of the eye,postoperative refractive status often experiences myopic shift.Additionally,complications such as suture exposure,IOL pupil capture,IOL dislocation,and retinal detachment may still occur,necessitating long-term close follow-up.These factors make the treatment of CEL challenging.This article reviews the surgical approaches,visual prognosis,postoperative refractive changes,and postoperative complications associated with CEL,aiming to provide a more comprehensive and in-depth understanding for the clinical diagnosis and treatment of this disease.关键词
先天性晶状体脱位/视力预后/屈光变化/术后并发症Key words
congenital ectopia lentis/visual prognosis/refractive changes/postoperative complications分类
医药卫生引用本文复制引用
刘思源,刘欣欣,叶倩,郑丹莹,张新愉,靳光明..先天性晶状体脱位的治疗及预后研究进展[J].眼科学报,2024,39(8):424-430,7.基金项目
国家自然科学基金(81873673,81900841) （81873673,81900841）
广东省自然科学基金(2021A1515011673,2022A1515011181) （2021A1515011673,2022A1515011181）
广州市基础研究计划市校(院)联合资助项目(SL2023A03J00514).This work was supported by the National Natural Science Foundation of China(81873673,81900841),Guangdong Basic and Applied Basic Research Foundation(2021A1515011673,2022A1515011181),and the Guangzhou Basic Research Program,City&University(Institute)Joint Funding Project(SL2023A03J00514),China. （院）
