医学信息2024，Vol.37Issue(19)：189-192,4.DOI:10.3969/j.issn.1006-1959.2024.19.041
中药雷公藤主要成分的毒副作用及解决策略
Toxicity and Side Effects of Main Components of Traditional Chinese Medicine Tripterygium Wilfordii and its Solution Strategy
摘要
Abstract
Traditional Chinese medicine Tripterygium wilfordii has curative effect on rheumatoid arthritis,diabetes mellitus,kidney disease and other diseases,but it has toxicity and side effects on liver,heart,kidney and other organ systems,resulting in safety problems in the use of Tripterygium wilfordii.With the progress of technology,a variety of attenuation strategies have gradually emerged.Researchers not only use processing,traditional Chinese medicine compatibility,change of dosage form and other methods to reduce toxicity and increase efficiency of Tripterygium wilfordii,but also use bioinformatics technology combined with a variety of modern biological methods to study the mechanism of toxic components of Tripterygium wilfordii,and then reduce its toxic components,which provides a new way to solve the toxic and side effects of Tripterygium wilfordii and improve its utilization rate.This review summarizes the existing screening methods for extracting toxic components of Tripterygium wilfordii,and discusses the use of bioinformatics methods to predict the targets of toxic components of Tripterygium wilfordii,laying a foundation for the attenuation of Tripterygium wilfordii.关键词
雷公藤/毒副作用/减毒策略Key words
Tripterygium wilfordii/Toxicity and side effects/Attenuation strategies分类
医药卫生引用本文复制引用
王怡然,温贵兰,杨颖..中药雷公藤主要成分的毒副作用及解决策略[J].医学信息,2024,37(19):189-192,4.基金项目
贵州生态养殖鸡五种常发疫病防控技术研究与示范项目(编号:701389211107) （编号:701389211107）
