中国当代儿科杂志2024，Vol.26Issue(10)：1027-1033,7.DOI:10.7499/j.issn.1008-8830.2404095
小于胎龄早产儿胆汁淤积症的临床特征及危险因素
Clinical features and risk factors of cholestasis in small for gestational age preterm infants
摘要
Abstract
Objective To investigate the clinical features and risk factors of cholestasis in small for gestational age(SGA)preterm infants.Methods This study selected SGA preterm infants born at less than 37 weeks of gestation and admitted to the Department of Neonatology,Children's Hospital of Soochow University within 24 hours after birth.The infants were divided into two groups:a cholestasis group and a non-cholestasis group.Clinical data from July 2017 to June 2022 were collected and retrospectively analyzed.Results Among the 553 SGA preterm infants included,100 infants(18.1%)developed cholestasis.The incidence rates in different gestational age and birth weight groups were as follows:extremely preterm infants 50.0%,very preterm infants 46.6%,moderate preterm infants 32.7%,and late preterm infants 9.8%;birth weight(BW)<1 000 g 60.9%,1 000 g≤BW<1 500 g 33.9%,and 1 500 g≤BW<2 500 g 10.7%.Multivariate regression analysis showed that low birth weight,intracranial hemorrhage,duration of invasive ventilation,total amino acid accumulation in the second week,total lipid emulsion accumulation in the first week,and total lipid emulsion accumulation in the second week were independent risk factors for cholestasis in SGA preterm infants(P<0.05).Conclusions The incidence of cholestasis in SGA preterm infants increases with decreasing gestational age and birth weight.The occurrence of cholestasis in SGA preterm infants is influenced by multiple risk factors,including low birth weight,intracranial hemorrhage,invasive ventilation,and the accumulation of amino acids and lipid emulsions,highlighting the need for comprehensive treatment measures to reduce its occurrence.关键词
胆汁淤积症/临床特征/危险因素/小于胎龄儿/早产儿Key words
Cholestasis/Clinical feature/Risk factor/Small for gestational age/Preterm infant引用本文复制引用
陈瑜,朱雪萍..小于胎龄早产儿胆汁淤积症的临床特征及危险因素[J].中国当代儿科杂志,2024,26(10):1027-1033,7.基金项目
国家自然科学基金项目(82271741) （82271741）
江苏省卫生健康委员会医学科研课题重点项目(ZD2021013) （ZD2021013）
姑苏领军人才(GSWS2022055) （GSWS2022055）
临床科技高端平台和转化基地建设项目(ML13101523) （ML13101523）
苏州大学附属儿童医院"遂园"临床研究项目(SY003). （SY003）
