中国临床医学2024，Vol.31Issue(5)：772-777,6.DOI:10.12025/j.issn.1008-6358.2024.20240453
Yes关联蛋白1在食管鳞状细胞癌中的临床意义
Clinical significance of Yes-associated protein 1 in esophageal squamous cell carcinoma
摘要
Abstract
Objective To explore the expression and clinical significance of Yes-associated protein 1(YAP1)in esophageal squamous cell carcinoma.Methods Immunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carcinoma.The differences of YAP1 expression and clinical parameters were analyzed between YAP1 positive group and YAP1 negative group.Kaplan-Meier curve was used to analyze the influence of YAP1 expression on survival of patients.Results The positive rate of YAP1 in esophageal squamous cell carcinoma was 30.52% .The tumor invasion was deeper in YAP1 positive group(P＜0.001).Kaplan-Meier survival analysis showed that YAP1 positive patients had longer disease-free survival(DFS)and overall survival(OS)among patients surviving longer than 30 months(P＜0.05).The multivariate Cox regression analysis showed that the invasion depth of tumor was an independent factor affecting DFS(HR=1.371,95% CI 0.993-1.894,P=0.035)and OS(HR=1.489,95% CI 1.066-2.080,P=0.020).Conclusions YAP1 has a certain percentage of positive rate in esophageal squamous cell carcinoma;for patients with survival longer than 30 months,YAP1 positive indicates a better prognosis.关键词
食管鳞状细胞癌/Yes关联蛋白1/预后Key words
esophageal squamous cell carcinoma/Yes-associated protein 1/prognosis分类
医药卫生引用本文复制引用
刘坤,管瑛瑛,蒋冬先,许惠娟,侯英勇,侯君..Yes关联蛋白1在食管鳞状细胞癌中的临床意义[J].中国临床医学,2024,31(5):772-777,6.基金项目
福建省卫生健康科技计划项目(2023QNB011),厦门市医疗卫生指导性项目(3502Z20224ZD1089,3502Z20244ZD1125),复旦大学附属中山医院厦门医院院级孵化课题(2018ZSXMYJ01).Supported by Health Science and Technology Program of Fujian Province(2023QNB011),Medical and Health Guidance Project of Xiamen(3502Z20224ZD1089,3502Z20244ZD1125),Incubation Subject of Zhongshan Hospital(Xiamen Branch),Fudan University(2018ZSXMYJ01). （2023QNB011）
