中国临床医学2024，Vol.31Issue(5)：790-794,5.DOI:10.12025/j.issn.1008-6358.2024.20240545
迟缓认知节奏对托莫西汀治疗儿童注意缺陷多动障碍疗效的影响
Effect of sluggish cognitive tempo on the efficacy of atomoxetine in children with attention-deficit/hyperactivity disorder
摘要
Abstract
Objective To explore the impact of sluggish cognitive tempo(SCT)on the efficacy of atomoxetine in the treatment of attention-deficit/hyperactivity disorder(ADHD).Methods A prospective study was conducted.Pediatric patients aged 6-12 years with a diagnosis of ADHD were selected from the Department of Psychiatry,Xijing Hospital,Air Force Military Medical University from May 2020 to May 2023.All the patients were treated with atomoxetine for 8 weeks.ADHD symptoms and SCT symptoms were assessed by Swanson,Nolan,and Pelham-Ⅳrating scale(SNAP-Ⅳ)and SCT rating scale at baseline(before treatment),4 weeks and 8 weeks after treatment.Pearson correlation analysis was used to analyze the correlation between SCT and SNAP-Ⅳscores.Results A total of 61 pediatric patients were enrolled,including 10 cases of inattentive type and 51 cases of mixed type.Baseline SCT score was positively correlated with baseline SNAP-Ⅳscore(r=0.490,P＜0.001)and reduction rate of SNAP-Ⅳscore at week 8(r=0.670,P＜0.001).The total SCT score at week 8 was positively correlated with total SNAP-Ⅳscore at baseline(r=0.320,P=0.012).The baseline SCT score of patients with mixed type was positively correlated with reduction rate of SNAP-Ⅳscore at week 8(r=0.578,P＜0.001).Conclusions The severity of SCT symptoms is positively correlated with the SNAP-Ⅳreduction rate 8 weeks after atomoxetine treatment,which could be a predictor of the efficacy of atomoxetine.关键词
注意缺陷多动障碍/迟缓认知节奏/托莫西汀/疗效Key words
attention-deficit/hyperactivity disorder/sluggish cognitive tempo/atomoxetine/efficacy分类
医药卫生引用本文复制引用
武文珺,吴迪,徐淑莉,于欢,蔡敏..迟缓认知节奏对托莫西汀治疗儿童注意缺陷多动障碍疗效的影响[J].中国临床医学,2024,31(5):790-794,5.基金项目
陕西省自然科学基础研究计划一般项目(2022JQ-908),陕西省重点研发计划一般项目(2023-YBSF-444),西京医院助推项目(XJZT24JC35).Supported by General Project of Shaanxi Natural Science Foundation(2022JQ-908),General Project of Shaanxi Key R&D Program(2023-YBSF-444)and the Boost Program of Xijing Hospital(XJZT24JC35). （2022JQ-908）
