中国人兽共患病学报2024，Vol.40Issue(9)：834-840,7.DOI:10.3969/j.issn.1002-2694.2024.00.130
2021-2022年广东省5岁以下婴幼儿腹泻病例中A组轮状病毒分子流行病学分析
Molecular epidemiological analysis of group A rotavirus in diarrhea cases in children under 5 years of age in Guangdong Province,2021-2022
摘要
Abstract
This study investigated the epidemiological and genotypic characteristics of group A rotavirus(RVA)in children under 5 years of age with diarrhea at a viral diarrhea surveillance sentinel hospital in Guangdong Province from 2021 to 2022,to provide a basis for RVA prevention and control.A total of 1 858 fecal samples from children under 5 years of age with diarrhea in 2021-2022 were collected.Rotavirus antigen was detected with ELISA,and positive samples were further sequenced and categorized.Among the 1 858 samples,156 were RVA positive.The positivity rates in boys and girls were 8.76％and 7.87％,respectively.Significant differences were observed in the detection rates of RVA infection among age groups.The rate of RVA infection increased gradually from December to April of the following year.In 2021,the main endemic strains of RVA in the Guangdong region were of the G9P[8]subtype,and the rare G8P[8]subtype increased in China.In 2022,the G8P[8]subtype surpassed the G9P[8]subtype for the first time.In cases of diarrhea in infants younger than 5 years in Guangdong Province from 2021 to 2022,the RVA genotypes were diverse,the G9P[8]genotype significantly decreased,and the G8P[8]subtype became a dominant genotype.Continuous RVA genotype monitoring remains necessary to assess the risk of RVA-related disea-ses.关键词
轮状病毒/病毒性腹泻/基因分型Key words
rotavirus/viral diarrhea/genotype分类
医药卫生引用本文复制引用
李彩霞,张昌,张薇,曾汉日,郑焕英,李柏生,柯碧霞..2021-2022年广东省5岁以下婴幼儿腹泻病例中A组轮状病毒分子流行病学分析[J].中国人兽共患病学报,2024,40(9):834-840,7.基金项目
Supported by the Medical Science and Technology Research Fund of Guangdong Province(No.A2022472)and the Guang-dong Provincial Key Laboratory of Pathogen Detection for E-mer-ging Infectious Disease Response(No.2023B1212010010) 广东省医学科学技术研究基金项目(No.A2022472)和广东省新发传染病应急检测技术研究与应用重点实验室项目(No.2023-B1212010010) （No.A2022472）
