中国人兽共患病学报2024，Vol.40Issue(9)：860-866,7.DOI:10.3969/j.issn.1002-2694.2024.00.134
鼠疫耶尔森菌LPS结构变异机制及其免疫逃逸功能研究进展
Advances in lipopolysaccharide structural variations and immune escape in Yersinia pestis
摘要
Abstract
Plague,caused by Yersinia pestis,is a zoonotic disease that infects both humans and animals.Y.pestis not only encodes various virulence factors that can disrupt host immune signaling but also can modify its lipopolysaccharide(LPS)struc-ture,thereby evading host immune surveillance and potently suppressing the host's immune response,in an important molecu-lar mechanism underlying its high pathogenicity.The LPS of Y.pestis lacks an O antigen,and its lipid A structure possesses a unique temperature transition regulatory mechanism.At different temperatures,Y.pestis forms lipid A with different numbers of acyl side chains,which plays a pivotal role in the evasion of host innate immune recognition and clearance.Here,we present a comprehensive review of research progress in the biosynthetic regulation,structural variation,and immune escape mechanism of Y.pestis LPS,to provide a reference for the study of the molecular mechanisms of pathogens using LPS structural modifica-tions to elude host innate immune defenses.关键词
鼠疫菌/脂多糖/免疫逃逸Key words
Yersinia pestis/lipopolysaccharide(LPS)/immune escape分类
医药卫生引用本文复制引用
冯文静,张源,杜宗敏..鼠疫耶尔森菌LPS结构变异机制及其免疫逃逸功能研究进展[J].中国人兽共患病学报,2024,40(9):860-866,7.基金项目
Supported by the State Key Laboratory of Pathogen and Biosecurity(No.SKLPBS2211) 病原微生物生物安全全国重点实验室自主课题(No.SKLPBS2211) （No.SKLPBS2211）
