品牌与标准化Issue(6)：32-35,4.DOI:10.3969/j.issn.1674-4977.2024.06.010
注射用头孢西丁钠在不同配伍溶液中的稳定性研究
Stability Study of Cefotaxime Sodium for Injection in Different Compatibility Solutions
黄健 1朱龙德1
作者信息
- 1. 海口市制药厂有限公司,海南 海口 570311
- 折叠
摘要
Abstract
Objective:To investigate the stability of cefoxitin sodium for injection and reference preparations in different compatibility solutions.Method:A compatibility test is conducted using ceftriaxone sodium for injection and a reference formulation in 0.9％ sodium chloride injection and 5％ glucose injection.The content,related substances,acidity,visible foreign substances,clarity and color of the solution,insoluble particles,and 5-hydroxymethylfurfural are measured at various time points to evaluate the stability of the self-made formulation and the compatibility solution,as well as the consistency with the reference formulation.Result:Within 0 h,3 h,6 h,and 12 h,the trend of changes between the self-made formulation and the reference formulation is basically consistent.Conclusion:Cefotaxime sodium for injection has good stability in different compatibility solutions and meets clinical medication requirements.关键词
注射用头孢西丁钠/配伍/稳定性Key words
cefotaxime sodium for injection/compatibility/stability引用本文复制引用
黄健,朱龙德..注射用头孢西丁钠在不同配伍溶液中的稳定性研究[J].品牌与标准化,2024,(6):32-35,4.
