肿瘤预防与治疗2024，Vol.37Issue(10)：904-911,8.DOI:10.3969/j.issn.1674-0904.2024.10.010
调控线粒体质量逆转肺癌放疗抵抗的研究进展
Research Progress of Mitochondrial Quality Control in Reversing Radiore-sistance in Lung Cancer
摘要
Abstract
Radiotherapy is one of the most important treatments against lung carcinomas in clinical practice.However,there are still many problems and challenges in radiotherapy for the eradication of lung cancers.Among them,it is urgent to overcome radioresistance and enhance immune responses for patients with lung cancers.Mitochondria are important organ-elles which modulate the occurrence,development and treatments of cancers.Moreover,mitochondrial quality control(MQC)is closely associated with the radioresistance of lung cancer.In this review,we summarized how MQC regulated and reversed the radioresistance of lung cancer from many aspects,including mitochondrial metabolism,mitochondrial chaper-ones,mitochondrial dynamics,mitochondrial autophagy,mitochondrial redox level,and mitochondria-mediated cell death,in order to provide evidence for immunotherapy combined with radiotherapy for lung cancers.关键词
肺癌/线粒体/放射治疗/放疗抵抗Key words
Lung cancer/Mitochondria/Radiotherapy/Radioresistance分类
医药卫生引用本文复制引用
雷旭丹,黄宇君,黄灵潇,徐珍妮,刘登群..调控线粒体质量逆转肺癌放疗抵抗的研究进展[J].肿瘤预防与治疗,2024,37(10):904-911,8.基金项目
四川省卫健委干部保健科研课题(编号:川干研2021-803,川干研2023-802) （编号:川干研2021-803,川干研2023-802）
四川省科技厅项目(编号:2021YJ0194,2022ZYD0091,2023JDRC0019) （编号:2021YJ0194,2022ZYD0091,2023JDRC0019）
四川省肿瘤医院项目(编号:YB2023015) This study was supported by grants from Health Commission of Sichuan Province(No.2021-803,No.2023-802),Science and Technology Department of Sichuan Province(No.2021YJ0194,No.2022ZYD0091,No.2023JDRC0019)and Sichuan Cancer Hospital(No.YB2023015). （编号:YB2023015）
