生命科学仪器2024，Vol.22Issue(5)：99-101,3.DOI:10.11967/2024221033
糖尿病肾病患者血清单核细胞趋化蛋白-1与白介素-6及糖代谢的关系
Relationship between Serum Monocyte Chemoattractant Protein-1 And Interleukin-6 And Glucose Metabolism in Patients with Diabetes Nephropathy
刘玉珂 1刘玉婷 2李建蕾3
作者信息
- 1. 山东省立第三医院,山东济南 250000
- 2. 山东省中医院,山东济南 250000
- 3. 山东省公共卫生临床中心,山东济南 250000
- 折叠
摘要
Abstract
Objective:To explore the relationship between serum monocyte chemoattractant protein-1(MCP-1)、interleukin(IL)-6 and glucose metabolism in patients with diabetes nephropathy(DN),so as to provide reference for the diagnosis and treatment of DN.Methods:A total of 145 T2DM patients admitted to our hospital from Janu-ary 2022 to February 2023 were collected.According to whether DN occurred,there were 90 cases in the simple T2DM group,30 cases in the early DN group,and 25 cases in the clinical DN group.The levels of serum MCP-1、IL-6 and glucose metabolism indexes in each group were compared,and the relationship between serum MCP-1、IL-6 and glucose metabolism indexes in DN patients was analyzed.Results:The levels of MCP-1、IL-6、FBP、HbA1c、FINS and HOMA-IR in clinical DN group and early DN group were significantly higher than those in T2DM group,P＜0.05.The levels of MCP-1、IL-6、FBP、HbA1c、FINS and HOMA-IR in clinical DN group were significantly higher than those in early DN group,P＜0.05.Linear correlation analysis showed that serum MCP-1 and IL-6 levels in DN patients were positively correlated with FBP、HbA1c、FINS and HOMA-IR(P＜0.05).Conclusion:The levels of serum MCP-1 and IL-6 in DN patients were positively correlated with their glu-cose metabolism disorders.In clinical practice,the level of serum MCP-1 and IL-6 in diabetes patients can be measured to assess their glucose metabolism disorders.关键词
糖尿病肾病/单核细胞趋化蛋白-1/白细胞介素-6/糖代谢Key words
Diabetes nephropathy/Monocyte chemotactic protein-1/Interleukin-6/Sugar metabolism分类
医药卫生引用本文复制引用
刘玉珂,刘玉婷,李建蕾..糖尿病肾病患者血清单核细胞趋化蛋白-1与白介素-6及糖代谢的关系[J].生命科学仪器,2024,22(5):99-101,3.
