中国临床药理学杂志2024，Vol.40Issue(20)：2954-2957,4.DOI:10.13699/j.cnki.1001-6821.2024.20.009
罗哌卡因复合地塞米松胸椎旁神经阻滞用于胸腔镜肺癌患者根治术的临床研究
Clinical trial of thoracic paravertebral nerve block with ropivacaine and dexamethasone in the treatment of patients undergoing thoracoscopic radical resection of lung cancer
陈曲敏 1蔡东妙1
作者信息
- 1. 厦门大学附属第一医院麻醉手术室,福建厦门 361003
- 折叠
摘要
Abstract
Objective To analyze the effects of thoracic paravertebral block(TPVB)with ropivacaine and dexamethasone on anesthesia quality and postoperative pain in patients undergoing thoracoscopic radical resection of lung cancer.Methods Patients with lung cancer who underwent thoracoscopic surgery under general anesthesia were divided into control group and treatment group by cohort method.Control group received 15 mL of 0.5％ropivacaine injection for TPVB;and treatment group was given 15 mL of 0.5％ropivacaine injection combined with 0.15 mg·kg-1 dexamethasone injection for TPVB.The TPVB effect(TPVB onset time,duration,the number of effective analgesic pump compressions with in 48 hours after surgery),mean arterial pressure(MAP),heart rate(HR),visual analogue scale(VAS)scores at rest and coughing after surgery,quality of recovery-40 questionnaire(QoR-40)score and occurrence of adverse drug reactions were compared between the two groups.Results There were 48 patients in treatment group and 52 patients in control group.The TPVB onset times in control group and treatment group were(10.86±1.93)and(7.21±1.15)min;the durations of TPVB were(400.27±33.15)and(859.73±50.69)min;the number of effective analgesic pump compressions were(13.42±3.70)and(7.18±1.94)times;the VAS scores at rest at 24 hours after surgery were(2.45±0.48)and(2.08±0.35)points;the VAS scores at coughing at 24 hours after surgery were(3.85±0.44)and(3.59±0.39)points,the QoR-40 scores at 3 days after surgery were(152.97±9.49)and(175.30±6.14)points.There were statistically significant differences in the above indexes between the treatment group and the control group(all P＜0.05).There were no statistically significant differences in MAP and HR at T0-T3 between the two groups(all P＞0.05).The total incidence rates of adverse drug reactions in treatment group and control group were 10.42％(5 cases/48 cases)and 11.54％(6 cases/52 cases),respectively(P＞0.05).Conclusion Ropivacaine combined with dexamethasone for TPVB can significantly improve the anesthesia quality,relieve the postoperative pain and promote the postoperative recovery in patients undergoing thoracoscopic surgery for lung cancer under general anesthesia,and it has high safety.关键词
罗哌卡因注射液/地塞米松注射液/胸椎旁神经阻滞/肺癌/胸腔镜/麻醉质量/术后疼痛Key words
ropivacaine injection/dexamethasone injection/thoracic paravertebral block/lung cancer/thoracoscope/anesthesia quality/postoperative pain分类
药学引用本文复制引用
陈曲敏,蔡东妙..罗哌卡因复合地塞米松胸椎旁神经阻滞用于胸腔镜肺癌患者根治术的临床研究[J].中国临床药理学杂志,2024,40(20):2954-2957,4.
