中国临床药理学杂志2024，Vol.40Issue(20)：2963-2967,5.DOI:10.13699/j.cnki.1001-6821.2024.20.011
帕瑞昔布钠联合右美托咪定用于骨质疏松压缩骨折患者手术的临床研究
Clinical trial of parecoxib sodium combined with dexmedetomidine for surgery in patients with osteoporotic compression fractures
罗凯 1王清 2王高举 2杨进 2李广州 2宋世杰 3蔡顺贵4
作者信息
- 1. 西南医科大学附属医院脊柱外科,四川泸州 646000||雅安市第二人民医院骨科,四川雅安 625000
- 2. 西南医科大学附属医院脊柱外科,四川泸州 646000
- 3. 雅安市第二人民医院骨科,四川雅安 625000
- 4. 雅安市第二人民医院麻醉科,四川雅安 625000
- 折叠
摘要
Abstract
Objective To investigate the effects of parecoxib sodium injection combined with dexmedetomidine hydrochloride injection on postoperative cognitive function and stress response in patients with osteoporotic compression fractures.Methods The patients with osteoporotic compression fractures were divided into treatment group and control group according to the treatment plan.The control group was given intravenous injection of dexmedetomidine hydrochloride injection 0.2 μg·kg-1load dose,then micro pump injection 0.2 μg·kg-1·min-1 maintenance dose,until 30 min before the end of the operation;patients in the treatment group were intravenously injected with parecoxib sodium injection 20 mg before local anesthesia and 30 min before the end of operation on the basis of the control group.The pain,sedation,hemodynamics[mean arterial pressure(MAP),heart rate(HR)],cognitive function and safety evaluation were compared between the two groups before operation(T0),2 h after operation(T1),6 h after operation(T2),12 h after operation(T3)and 24 h after operation(T4).Results There were 39 cases in the treatment group and 41 cases in the control group.Visual analogue scale(VAS)scores in treatment group and control group were(3.09±0.55)and(3.41±0.62)scores at T1;VAS scores were(3.02±0.57)and(3.35±0.48)scores at T2;VAS scores were(2.64±0.44)and(2.90±0.46)scores at T3;VAS scores were(2.02±0.41)and(2.35±0.47)scores at T4;MMSE scores were(25.28±1.57)and(24.33±1.42)scores at T2;MMSE scores were(28.16±1.01)and(27.25±0.89)scores at T4;MoCA scores were(24.63±1.60)and(23.59±1.25)scores at T2;MoCA scores were(27.20±0.97)and(26.48±0.83)scores at T4.There were statistically significant differences in the above indexes between the treatment group and the control group(all P＜0.05).Adverse drug reactions in the treatment group included bradycardia,hypotension,nausea vomiting and hypokalemia;adverse drug reactions in the control group included bradycardia,hypotension and nausea vomiting.The total incidence rates of adverse drug reactions were 12.82％and 9.76％,without statistically significant difference(P＞0.05).Conclusion Compared with using dexmedetomidine alone,parecoxib sodium combined with dexmedetomidine is beneficial for relieving postoperative pain in patients with osteoporotic compression fractures,improving postoperative cognitive function.关键词
注射用帕瑞昔布钠/右美托咪定注射液/骨质疏松压缩骨折/认知功能/应激反应Key words
parecoxib sodium injection/dexmedetomidine hydrochloride injection/osteoporotic compression fractures/cognitive function/stress reaction分类
医药卫生引用本文复制引用
罗凯,王清,王高举,杨进,李广州,宋世杰,蔡顺贵..帕瑞昔布钠联合右美托咪定用于骨质疏松压缩骨折患者手术的临床研究[J].中国临床药理学杂志,2024,40(20):2963-2967,5.
