中国临床药理学杂志2024，Vol.40Issue(20)：2978-2982,5.DOI:10.13699/j.cnki.1001-6821.2024.20.014
地奈德乳膏联合盐酸西替利嗪治疗尿毒症血液透析皮肤瘙痒患者的临床研究
Clinical trial on the combination of dinald cream and sertraline hydrochloride for skin itching in hemodialysis patients with uremic blood
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of desonide cream in combination with cetirizine hydrochloride for the treatment of skin itching in patients with uremia undergoing hemodialysis.Methods Patients with skin itching associated with uremia and hemodialysis were divided into control group and treatment group by random number table.The control group received oral cetirizine hydrochloride,10 mg per dose,once daily for 8 weeks.Patients in the treatment group were treated with desonide cream appropriate amout for external use on the basis of the treatment in the control group,once in the morning and once in the evening every day,and smeared on the pruritus of the patient's skin for 8 weeks.The clinical efficacy of the two groups were compared,and the pruritus symptoms,sleep quality and safety evaluation of the two groups were compared.Results During the trial,a total of 36 cases dropped out,with 52 cases ultimately included in the treatment and control groups,respectively.Following treatment,the total effective rates in the treatment and control groups were 82.69％(43 cases/52 cases)and 63.46％(33 cases/52 cases),respectively,showing statistically significant difference(P＜0.05).After treatment,the visual analog scale(VAS)scores for the treatment and control groups were(2.87±1.29)and(3.62±1.76)points,respectively;the modified Dou's analogue grading(Dou's VAG)were(18.24±3.23)and(20.13±4.59)points,respectively;the Pittsburgh sleep quality index(PSQI)scores were(9.57±1.72)and(10.34±2.01)points,respectively.Compared with the control group,the above indexes in treatment group were statistically significant(all P＜0.05).The adverse drug reactions of the treatment group were dizziness,nausea and vomiting,and the adverse drug reactions of the control group were dizziness,nausea and vomiting.The total incidence of adverse drug reactions in the treatment group and the control group was 9.62％(5 cases/52 cases)and 7.69％(4 cases/52 cases),respectively,and the difference was no statistically significant(P＞0.05).Conclusion The combination of desonide cream and cetirizine hydrochloride has better efficacy and safety than cetirizine hydrochloride alone in treating the itching symptoms of uremic hemodialysis patients.关键词
地奈德乳膏/盐酸西替利嗪片/尿毒症血液透析/皮肤瘙痒/睡眠质量/红细胞免疫功能/炎症因子/微小RNA-146aKey words
desonide cream/cetirizine hydrochloride tablet/uremic hemodialysis/skin itching/sleep quality/erythrocyte immune function/inflammatory factors/microRNAs-146a分类
医药卫生引用本文复制引用
陈晓霞,谢席胜,占志朋..地奈德乳膏联合盐酸西替利嗪治疗尿毒症血液透析皮肤瘙痒患者的临床研究[J].中国临床药理学杂志,2024,40(20):2978-2982,5.基金项目
成都中医药大学"杏林学者"学科人才科研提升计划研究专项基金资助项目(YYZX2020088) （YYZX2020088）
