北京中医药大学学报2024，Vol.47Issue(10)：1333-1342,10.DOI:10.3969/j.issn.1006-2157.2024.10.001
基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制
Exploration the modern scientific connotations of traditional Chinese medicine theory and therapeutic mechanism of Chinese materia medica based on extracellular vesicles
摘要
Abstract
Extracellular vesicles(EVs)are secreted by various cells and carry information such as parent cell-derived RNA,DNA,proteins,and lipids.They mediate information exchange between cells and organs,playing a crucial role in disease occurrence and development,diagnosis,treatment,and targeted drug delivery.EVs are also closely associated with traditional Chinese medicine theories and treatments.The qi-blood-fluid and visceral outward manifestation theories are the fundamental theories of traditional Chinese medicine.EVs belong to the fluid category and can reach other viscera through the blood vessels.They regulate the relationship between the viscera or cause imbalances between the viscera,resulting in disease.Chinese materia medica,which primarily includes traditional Chinese patent medicines and simple preparations,and Chinese herbal medicine,can help regulate the quantity and content of endogenous EVs in the body to improve pathological conditions.Additionally,EV-like particles derived from herbal medicines are a major form of pharmacologically active substances that contribute to the therapeutic effects of Chinese medicine in treating diseases.Furthermore,EVs can also be used as carriers to deliver drugs for targeted therapy.Therefore,exploring the relationship between traditional Chinese medicine and EVs will elucidate the modern scientific connotation of traditional Chinese medicine theories and reveal the mechanism of Chinese materia medica.The development of engineered EVs based on Chinese materia medica will provide novel strategies for clinical treatment.关键词
细胞外囊泡/中医学理论/中药/中草药来源细胞外囊泡样颗粒Key words
extracellular vesicles/traditional Chinese medicine theories/Chinese materia medica/Chinese herbal medicine-derived EV-like particles分类
医药卫生引用本文复制引用
赵明镜..基于细胞外囊泡阐释中医学理论现代科学内涵和中药治疗机制[J].北京中医药大学学报,2024,47(10):1333-1342,10.基金项目
国家自然科学基金面上项目(No.81973787,No.82104653) （No.81973787,No.82104653）
北京中医药大学揭榜挂帅项目(No.90011431110008) （No.90011431110008）
北京市通州区科技创新人才项目(No.JCON2023020) National Natural Science Foundation of China(Nos.81973787 and 82104653) （No.JCON2023020）
