北京中医药大学学报2024，Vol.47Issue(10)：1355-1359,5.DOI:10.3969/j.issn.1006-2157.2024.10.004
原发性多发肺结节"炎癌转化"机制探讨
Discussion on the mechanism of the"inflammation-cancer transformation"in primary multiple pulmonary nodules
摘要
Abstract
Primary multiple pulmonary nodules have a high incidence,and the size and number of pulmonary nodules on computed tomography images increase with time.Postoperative pathology of multiple pulmonary nodules shows chronic inflammation,adenomatoid change,carcinoma in situ,microinvasive carcinoma,infiltrating carcinoma,and other forms.There is a possibility of"inflammation-cancer transformation"in multiple pulmonary nodules with prolonged time and external irritation.The accumulation of dampness phlegm and blood stasis is the basis of the theory of"inflammation-cancer transformation."Healthy qi deficiency is the key to the"inflammation-cancer transformation."Qi and yang deficiency are the root cause of healthy qi depletion.Emotional depression,dampness,phlegm,and blood stasis transforming into toxins provide the impetus for"inflammation-cancer transformation."There are struggle between healthy qi and evil qi,and waxing and waning of dampness,phlegm and blood stasis in the process of"inflammation-cancer transformation."The dampness phlegm and blood stasis will increase when evil qi increases and healthy qi decreases.In contrast,the size,number,and malignancy of nodules will increase during healthy qi deficiency,showing a dynamic shift from inflammation to atypical adenomatous hyperplasia to cancer.The dampness phlegm and blood stasis will be absorbed as the healthy qi increases and evil qi decreases so that lung cancer can be reversed.External irritation,such as acute inflammatory stimulation,may accelerate the transformation of"inflammation-cancer"in multiple pulmonary nodules.关键词
原发性多发肺结节/炎癌转化/正气亏耗/情志郁结/湿痰瘀停聚/治未病Key words
primary multiple pulmonary nodules/inflammation-cancer transformation/health qi deficiency/emotional depression/dampness phlegm and blood stasis accumulation/preventive treatment of disease分类
医药卫生引用本文复制引用
李梦乾,张晓梅,姜良铎,赖宇鑫..原发性多发肺结节"炎癌转化"机制探讨[J].北京中医药大学学报,2024,47(10):1355-1359,5.基金项目
首都卫生发展科研专项(No.2020-2-4202) （No.2020-2-4202）
北京中医药大学2024年基本科研业务费"揭榜挂帅"项目(No.2024-JYB-JBZD-009) Capital Health Development Research Project(No.2020-2-4202) （No.2024-JYB-JBZD-009）
