北京中医药大学学报2024，Vol.47Issue(10)：1360-1366,7.DOI:10.3969/j.issn.1006-2157.2024.10.005
基于"态靶因果"探析慢性胰腺炎"炎癌转化"的病机演变与论治策略
Analysis of pathogenesis evolution and therapeutic strategies for"inflammation-cancer transformation"in chronic pancreatitis based on"state-target-cause-result"
摘要
Abstract
"State-target-cause-result"is a new clinical theory combining macroscopic and microscopic syndrome differentiation based on the holistic view of traditional Chinese medicine combined with Western medical research.The"inflammation-cancer transformation"of chronic pancreatitis is a complex pathological process that is associated with the interaction between the pancreas and various pathological factors and multiple objects,involving the imbalance of multiple homeostasis.The microscopic process of"inflammation-cancer transformation"in chronic pancreatitis is the"target,"whereas various factors that could induce its occurrence under chronic inflammatory conditions are the"state."The"inflammation-cancer transformation"of chronic pancreatitis is summarized as yin and yang imbalance,qi movement disorder,endogenous dampness,heat,blood stasis,and turbid phlegm stagnation,unresolved congestion resulting in deficiency caused by stagnation,intermingled deficiency and excess,and internal cancer toxin generation.This paper elucidates the pathogenesis and intervention strategies of the"inflammation-cancer transformation"of chronic pancreatitis from a macro perspective of"state,"focusing on reducing the impact of"state"imbalance on the"target"to establish a balanced pancreas-immune-microbiota state.The aim is to broaden the theory for exploring the mechanism and drug development related to chronic pancreatitis"inflammation-cancer transformation"in both traditional Chinese and Western medicine.关键词
态靶因果/慢性胰腺炎/炎癌转化/胰腺癌/治未病Key words
state-target-cause-result/chronic pancreatitis/inflammation-cancer transformation/pancreatic cancer/preventive treatment of disease分类
医药卫生引用本文复制引用
戴云飞,尚东,项红,关溪,赵亮,白长川..基于"态靶因果"探析慢性胰腺炎"炎癌转化"的病机演变与论治策略[J].北京中医药大学学报,2024,47(10):1360-1366,7.基金项目
第七批全国老中医药专家学术经验继承工作(国中医药办人教函[2021]272号) （国中医药办人教函[2021]272号）
兴辽英才计划(No.XLYC2212013) The Seventh Batch of Academic Experience Inheritance Work of Senior Chinese Medicine Experts in China([2021]No.272) （No.XLYC2212013）
