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Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

Na Li Baohong Shi Zan Li Jie Han Jun Sun Haitao Huang Alisha R.Yallowitz Seoyeon Bok Shuang Xiao Zuoxing Wu Yu Chen Yan Xu Tian Qin Rui Huang Haiping Zheng Rong Shen Lin Meng Matthew B.Greenblatt Ren Xu

Bone Research2024，Vol.12Issue(3)：P.675-688,14.

Bone Research2024，Vol.12Issue(3)：P.675-688,14.DOI:10.1038/s41413-024-00349-1

Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

Na Li ¹Baohong Shi ¹Zan Li ²Jie Han ³Jun Sun ⁴Haitao Huang ³Alisha R.Yallowitz ⁵Seoyeon Bok ⁵Shuang Xiao ³Zuoxing Wu ³Yu Chen ³Yan Xu ⁶Tian Qin ⁶Rui Huang ³Haiping Zheng ¹Rong Shen ⁷Lin Meng ⁸Matthew B.Greenblatt ⁹Ren Xu¹

作者信息

1. State Key Laboratory of Cellular Stress Biology,Cancer Research Center,School of Medicine,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen 361102,China Fujian Provincial Key Laboratory of Organ and Tissue Regeneration,School of Medicine,Xiamen University,Xiamen 361102,China
2. State Key Laboratory of Cellular Stress Biology,Cancer Research Center,School of Medicine,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen 361102,China Department of Sports Medicine,Xiangya Hospital,Central South University,Changsha 410000,China
3. State Key Laboratory of Cellular Stress Biology,Cancer Research Center,School of Medicine,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen 361102,China
4. Research Division,Hospital for Special Surgery,New York,NY 10065,USA
5. Department of Pathology and Laboratory Medicine,Weill Cornell Medical College,New York,NY 10065,USA
6. Department of Sports Medicine,Xiangya Hospital,Central South University,Changsha 410000,China
7. Fujian Provincial Key Laboratory of Organ and Tissue Regeneration,School of Medicine,Xiamen University,Xiamen 361102,China
8. Department of Electronic and Computer Engineering,Ritsumeikan University,Kusatsu,Shiga 525-8577,Japan
9. Research Division,Hospital for Special Surgery,New York,NY 10065,USA Department of Pathology and Laboratory Medicine,Weill Cornell Medical College,New York,NY 10065,USA
折叠

摘要

关键词

skeletal/imperfect/endothelium

分类

医药卫生

引用本文复制引用

Na Li,Baohong Shi,Zan Li,Jie Han,Jun Sun,Haitao Huang,Alisha R.Yallowitz,Seoyeon Bok,Shuang Xiao,Zuoxing Wu,Yu Chen,Yan Xu,Tian Qin,Rui Huang,Haiping Zheng,Rong Shen,Lin Meng,Matthew B.Greenblatt,Ren Xu..Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta[J].Bone Research,2024,12(3):P.675-688,14.

基金项目

supported by the National Natural Science Foundation of China (81972034,92068104 and 82002262 to R.X.) （81972034,92068104 and 82002262 to R.X.）

the National Key R&D Program of China (2020YFA0112900 to R.X.) （2020YFA0112900 to R.X.）

Project of Xiamen Cell Therapy Research Center (3502Z20214001 to R.X.) （3502Z20214001 to R.X.）

supported by a the NIH grant of US (R01AR075585,R01HD115274,R01CA282815 to M.B.G.) （R01AR075585,R01HD115274,R01CA282815 to M.B.G.）

Career Award for Medical Scientists from the Burroughs Wellcome Fund （）

a Pershing Square Sohn Cancer Research Alliance and the Maximizing Innovation in Neuroscience Discovery (MIND)Prize （MIND）

supported by a Jump Start Research Career Development Award from Weill Cornell Medicine （）

a Study Abroad Scholarships from the Mogam Science Scholarship Foundation。（）

Bone Research

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ISSN：2095-4700

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