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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin

Neural Regeneration Research2025，Vol.20Issue(10)：P.3025-3039,15.

Neural Regeneration Research2025，Vol.20Issue(10)：P.3025-3039,15.DOI:10.4103/NRR.NRR-D-23-01879

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Jia Fang ¹Zhuangzhuang Li ²Pengjun Wang ²Xiaoxu Zhang ²Song Mao ²Yini Li ²Dongzhen Yu ²Xiaoyan Li ³Yazhi Xing ²Haibo Shi ²Shankai Yin²

作者信息

1. Department of Otolaryngology Head and Neck Surgery,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Otolaryngology Institute of Shanghai Jiao Tong University,Shanghai Key Laboratory of Sleep Disordered Breathing,Shanghai,China Department of Otorhinolaryngology-Head and Neck Surgery,Shanghai Children’s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
2. Department of Otolaryngology Head and Neck Surgery,Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Otolaryngology Institute of Shanghai Jiao Tong University,Shanghai Key Laboratory of Sleep Disordered Breathing,Shanghai,China
3. Department of Otorhinolaryngology-Head and Neck Surgery,Shanghai Children’s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
折叠

摘要

关键词

degeneration/hearing loss/macrophages/Mcc950/neuroinflammation/NLRP3 inflammasome/ototoxicity/pyroptosis/sensorineural hearing loss/spiral ganglion neuron

分类

医药卫生

引用本文复制引用

Jia Fang,Zhuangzhuang Li,Pengjun Wang,Xiaoxu Zhang,Song Mao,Yini Li,Dongzhen Yu,Xiaoyan Li,Yazhi Xing,Haibo Shi,Shankai Yin..Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss[J].Neural Regeneration Research,2025,20(10):P.3025-3039,15.

基金项目

supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW) （to YX）

the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY). （to HS）

Neural Regeneration Research

ISSN：1673-5374

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