中医康复2024，Vol.1Issue(10)：41-47,7.DOI:10.19787/j.issn.2097-3128.2024.10.009
中药调控类风湿性关节炎相关信号通路作用机制的研究进展
Advances in the Regulation of Signal Pathways Related to Rheumatoid Arthritis by Traditional Chinese Medicine
摘要
Abstract
Rheumatoid arthritis(RA)is a known chronic autoimmune disease that can cause joint deformities and even loss of joint function.Chinese medicine plays a significant role in the treatment of chronic orthopaedic diseases.According to reports,traditional Chinese medicine and its active in-gredients through the signaling pathway is an important way to treat RA.Therefore,this paper reviewed the currently available references on the therapeutic effects of traditional Chinese medicine on RA,and summarized the relevant signaling pathways.The main relevant signaling pathways were summarized as TLR4/MAPK/NF-κB signaling pathway,Wnt/β-catenin signaling pathway,OPG/RANKL/RANK signaling pathway,and WNT/RANKL signaling pathway.Pi3k-akt-mediated apoptosis pathway and Janus kinase/Signal transduction and Activator of Transcription(JAK-STAT)signaling pathway.Understanding the pathways of action of these Chinese medicines in RA is not only helpful to elucidate the molecular mechanism of Chinese medicines in the treatment of RA,but also conducive to finding new candidate therapeutic drugs from natural herbs.关键词
类风湿性关节炎/成纤维细胞/炎症/信号通路Key words
rheumatoid arthritis/fibroblast/inflammation/signal path分类
医药卫生引用本文复制引用
安文博,刘建军,张晓刚,左利平,陈一新,陈欣,齐鑫,南瑞雄..中药调控类风湿性关节炎相关信号通路作用机制的研究进展[J].中医康复,2024,1(10):41-47,7.基金项目
张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函2022-75号) （国中医药人教函2022-75号）
2022年甘肃省自然科学基金(22JR11RA126) （22JR11RA126）
2023年省级重点人才项目(002087001,2060208) （002087001,2060208）
国家中医骨伤优势专科项目(2023GS-02,2023GS-08) （2023GS-02,2023GS-08）
2021兰州市科技局指导性计划项目(2022-ZD-91) （2022-ZD-91）
甘肃省中医药科研课题(GZKZ-2022-4) （GZKZ-2022-4）
兰州市科技局社会发展科技科(2023-ZD-144) （2023-ZD-144）
2020院内创新基金(gzfy-2020-27) （gzfy-2020-27）
