中医康复2024，Vol.1Issue(11)：41-46,6.DOI:10.19787/j.issn.2097-3128.2024.11.009
健脾固肾颗粒的制备工艺和质量标准研究
Study on Production Process and Quality Standard of Jianpi Gushen Granulas
摘要
Abstract
Objective:To optimize the extraction and forming process of Jianpi Gushen granules and establish its quality standard.Methods:Orthogo-nal experiment design was used to optimize the extraction process.Single factor test was used to determine the optimal manufacturing process.The thin layer chromatography(TLC)was performed to identify Atractylodis Macrocephalae Rhizoma,Ligustri Lucidi Fructus,Phellodendri Chinensis Cortex of the Jianpi Gushen Granulas.Results:The optimum production process was to add 8 times water and extract 2 times for 1 h each time.The extraction solution was concentrated to a relative density of 1.10～1.15(80℃),With 0.8 to 1.5 times the amount of extractum dextrin,and sprayed granulated under the conditions of spray speed of 10～30 g/min,atomization pressure of 2～3 bar,inlet air temperature of 150～160℃and liquid tem-perature of 70～80℃.TLC had an impressive specialization,with no interference observed in comparison to the negative.Conclusion:The produc-tion process of Jianpi Gushen Granulas is rational and executable,and the simplicity and reliability of the thin-layer identification method are no-table,which provides the experimental basis for the development and utilization of this preparation.关键词
健脾固肾颗粒/配制工艺/质量标准Key words
Jianpi Gushen Granulas/production process/quality standard分类
医药卫生引用本文复制引用
吴典伟,陈展祥,陈雪婷,张靖年,黄茂胜,张建军,陈超..健脾固肾颗粒的制备工艺和质量标准研究[J].中医康复,2024,1(11):41-46,6.基金项目
广东省科技创新战略专项(No.STKJ202209074) （No.STKJ202209074）
