赣南医学院学报2024，Vol.44Issue(9)：905-910,6.DOI:10.3969/j.issn.1001-5779.2024.09.006
假体周围感染菌株分布的临床研究
Clinical study on the distribution of pathogen strains around periprosthetic joint infection
摘要
Abstract
Objective:To analyze the distribution of pathogen strains and the characteristics of drug sensitivity around periprosthetic joint infection(PJI),providing a basis for the selection of pathogen strains and drugs in experimental stud-ies.Methods:The clinical data of patients who underwent two-stage revision of artificial joints due to periprosthetic joint infection(PJI)in the Department of Artificial Joints and Knee Joints of the First Affiliated Hospital of Guangzhou Uni-versity of Chinese Medicine from August 2010 to December 2016 were collected.The strain distribution and results of drug sensitivity tests of these patients were analyzed.Results:A total of 77 patients were included in this study,among whom 51 patients(66.23% )had positive strain detections.There were 43 cases(84.31% )of Gram-positive strains,6 cases(11.77% )of Gram-negative strains,and 2 cases(3.92% )of fungi.The drug sensitivity tests revealed that:⑴The resistance rates of methicillin-sensitive staphylococcus aureus(MSSA),methicillin-resistant staphylococcus aureus(MRSA),and staphylococcus epidermidis to penicillin in Gram-positive bacteria were 84.62%,75.00%,and 100.00%,respectively.They were all sensitive to vancomycin,linezolid,daptomycin,and tigecycline.The resistance rates of MRSA and staphylococcus epidermidis to oxacillin were 100.00%、87.50%,while MSSA was sensitive.MSSA and staphylococcus epidermidis were sensitive to moxifloxacin and gentamicin,while MRSA was only sensitive to genta-micin.MSSA was sensitive to ciprofloxacin,levofloxacin,rifampicin,nitrofurantoin,and cotrimoxazole.⑵ The main Gram-negative bacteria were Klebsiella pneumoniae and Escherichia coli.The resistance rates of Klebsiella pneu-moniae to ciprofloxacin,gentamicin,nitrofurantoin,ampicillin,cefazolin,and aztreonam;the sensitivity rates to ceftazidime,piperacillin/tazobactam,imipenem,amikacin,and ertapenem.The resistance rates of Escherichia coli to ampicillin and cefazolin;the sensitivity rates to nitrofurantoin,ceftazidime,cefepime,piperacillin/tazobactam,imipenem,ertapenem,and cefotetan.⑶ The fungi were Candida parapsilosis and Candida tropicalis,and they were all sensitive to amphotericin B,fluconazole,voriconazole,itraconazole,and 5-fluorocytosine.Conclusion:Gram-positive cocci are the main pathogenic bacteria of PJI,among which MSSA is the main Gram-positive coccus,showing high resistance to various antibiotics.Fungi are sensitive to various antifungal drugs.关键词
感染,假体周围/菌株分布/药敏试验/抗药性,细菌Key words
Infection,periprosthetic joint/Pathogen strains/Drug sensitive test/Drug resistance,germs分类
医药卫生引用本文复制引用
孙小波,张世标,刘玉婷,曾意荣..假体周围感染菌株分布的临床研究[J].赣南医学院学报,2024,44(9):905-910,6.基金项目
赣州市科技局指导性科技计划项目(GZ2020ZSF357) （GZ2020ZSF357）
