摘要
Abstract
Objective To analyze the distribution characteristics and drug resistance of pathogens in patients with chro-nic obstructive pulmonary disease(COPD)complicated with pneumonia.Methods A total of 302 COPD patients with pneu-monia admitted to the Respiratory Department of the 95829th Military Hospital from January 2022 to December 2023 were se-lected as the subjects.Sputum culture,drug sensitivity test and pathogen isolation results were analyzed,and the resistance of major pathogens to common antibiotics was investigated.Results In 2022,231 strains of pathogenic bacteria were isolated from sputum samples of 154 COPD patients with pneumonia,and the distribution of bacteria from high to low were gram-nega-tive bacteria,fungi and gram-positive bacteria.In 2023,209 strains of pathogenic bacteria were isolated from sputum sam-ples of 148 COPD patients with pneumonia,and the distribution of bacteria from high to low were gram-negative bacteria,fungi,and gram-positive bacteria.In 2022 and 2023,39 strains and 40 strains of Pseudomonas aeruginosa were isolated re-spectively.Pseudomonas aeruginosa was completely resistant to amoxicillin/clavulanic acid and ampicillin,with low resist-ance rates to ciprofloxacin and amikacin,and did not developed resistance to colistin.In 2022 and 2023,36 strains and 37 strains of Klebsiella pneumoniae were isolated respectively.Klebsiella pneumoniae was completely resistant to ampicillin,had low resistance to fosfomycin,imipenem,and tigecycline,and had no resistance to colistin.Twenty-seven and 25 strains of Acinetobacter baumannii were isolated in 2022 and 2023 respectively.Acinetobacter baumannii was completely resistant to tobramycin,ampicillin,amoxicillin/clavulanic acid and levofloxacin,and did not develop resistance to colistin.In 2022 and 2023,24 and 22 strains of Escherichia coli were isolated respectively.All Escherichia coli had high resistance to ampicillin and piperacillin,low resistance to cefoperazone/sulbactam,imipenem,amikacin,phosphomycin and furantoin,and no re-sistance to tigecycline.Conclusions The pathogenic bacteria in COPD patients with pneumonia are complex,the distribution of pathogens is mainly gram-negative bacteria,and the resistance of common antibiotics in different pathogens is different.Antibiotics can be selected according to the results of sputum cul-ture and drug sensitivity test.关键词
慢性阻塞性肺疾病/肺炎/病原菌/分布特征/耐药性Key words
chronic obstructive pulmonary disease/pneumonia/pathogenic bacteria/distribution characteristics/drug resist-ance分类
医药卫生
