新医学2024，Vol.55Issue(10)：764-770,7.DOI:10.3969/j.issn.0253-9802.2024.10.002
呼出气一氧化氮检测在支气管哮喘诊治中的临床应用进展
Progress in the clinical application of fractional exhaled nitric oxide in diagnosis and treatment of bronchial asthma
摘要
Abstract
Fractional exhaled nitric oxide(FeNO)is a biomarker of type 2 inflammation,and produced by nitric oxide synthase(NOS)expressed on the airway epithelial cells,with the substrates of L-arginine and oxygen.Type 2 cytokines such as interleukin(IL)-4 and IL-13 can up-regulate inducible NOS,which results in the abundant production of NO.NO plays an important role in the pathogenesis of bronchial asthma,and is closely associated with the airway inflammation and remodeling,reduction of lung function and eosinophil infiltration,etc.The technique of FeNO test is applied in the clinical diagnosis of asthma,predicting the response to steroids and evaluating the compliance of asthmatic patients.In recent years,it also plays a guiding role in choosing the optimal biologics for individual therapy for patients of asthma.As a non-invasive,convenient,and economical method,the role of FeNO in the diagnosis and treatment of asthma will be better understood and applied.关键词
呼出气一氧化氮/2型炎症/支气管哮喘/白介素-4/白介素-13Key words
Fractional exhaled nitric oxide/T2 inflammation/Bronchial asthma/Interleukin-4/Interleukin-13引用本文复制引用
汪慧英..呼出气一氧化氮检测在支气管哮喘诊治中的临床应用进展[J].新医学,2024,55(10):764-770,7.基金项目
国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目重大项目(GZY-ZJ-KJ-23027) （GZY-ZJ-KJ-23027）
浙江省自然科学基金探索Y类项目(YLY20H260005) （YLY20H260005）
