新医学2024，Vol.55Issue(10)：818-827,10.DOI:10.3969/j.issn.0253-9802.2024.10.009
慢性鼻窦炎小鼠建模研究进展
Research progress in the establishment of mouse models of chronic rhinosinusitis
摘要
Abstract
Chronic nasal inflammation,such as rhinitis and sinusitis,is a common chronic disease that affects people's quality of life for a long period of time.Its pathogenesis and mechanism are still unclear.The establishment of animal models is an effective approach to explore the pathogenesis,among which the establishment of mouse models of chronic nasal inflammation has been rapidly developed in recent years.The aim of this review is to summarize the research status of chronic rhinosinusitis and allergic rhinitis modeling in mice at home and abroad,especially the progress in eosinophilic chronic rhinosinusitis mouse models,which plays an important role in the development of new drugs to prevent and control chronic nasal inflammation or further elucidation of its pathogenesis.关键词
小鼠模型/嗜酸性粒细胞/鼻息肉/慢性鼻窦炎/过敏性鼻炎Key words
Mouse model/Eosinophil/Nasal polyps/Chronic rhinosinusitis/Allergic rhinitis引用本文复制引用
陈源,沈暘,王吉,卢韬,郑博文,杨玉成..慢性鼻窦炎小鼠建模研究进展[J].新医学,2024,55(10):818-827,10.基金项目
国家自然科学基金(81970864) （81970864）
