中国临床药学杂志2024，Vol.33Issue(9)：661-666,6.DOI:10.19577/j.1007-4406.2024.09.004
集中带量采购替格瑞洛仿制药与原研药用于行支架辅助弹簧圈栓塞术颅内动脉瘤患者的有效性及安全性比较
Comparison of efficacy and safety of generic and branded ticagrelor in patients with intracranial stent placement before and after the implementation of the centralized volume-based procurement policy
摘要
Abstract
AIM To explore the efficacy and safety of generic branded ticagrelor after centralized volume-based procurement in patients with intracranial aneurysm undergoing stent-assisted coil embolization.METHODS Patients with intracranial aneurysms who underwent stent-assisted coil embolization from January 2020 to November 2021 were included and divided into 2 groups according to the use of ticagrelor varieties before centralized volume-based procurement(January to November 2020)and after procurement(December 2020 to November 2021).The inhibition rate of platelet aggregation function after medication in the hospital was recorded in 2 groups.The modified Rankin scale(mRS),Glasgow outcome scale(GOS)and incidence of ischemic and bleeding events were followed up 6 months after discharge,and the above indexes were compared between the 2 groups.RESULTS The ADP inhibition rates during hospitalization for the post-centralized procurement group and the pre-centralized procurement group were(59.01±29.05％vs 62.35±27.62％),and the achievement rates for the ADP inhibition rates were(60.00％vs 64.86％),respectively,with no statistical difference(P＞0.05).At 6 months post-discharge,the incidence rates of ischemic events(5.88％vs 4.71％),bleeding events(18.82％vs 15.29％),and the scores for the GOS(4.89±7.05 vs 4.85±7.12)and the mRS(0.50±0.21 vs 0.62±0.24)were also compared between the post-centralized procurement group and the pre-centralized procurement group,with no statistical difference(P＞0.05).CONCLUSION For patients with intracranial aneurysmal who undergo stent-assisted coil embolization,there is no significant difference in the efficacy and safety of generic and branded ticagrelor before and after centralized volume-based procurement.关键词
集中带量采购/替格瑞洛/颅内动脉瘤/支架辅助弹簧圈栓塞术Key words
centralized volume-based procurement/ticagrelor/intracranial aneurysm/stent-assisted coil embolization引用本文复制引用
李一辰,伊曼曼,邵腾飞,庄宗,那世杰,李俐,葛卫红..集中带量采购替格瑞洛仿制药与原研药用于行支架辅助弹簧圈栓塞术颅内动脉瘤患者的有效性及安全性比较[J].中国临床药学杂志,2024,33(9):661-666,6.基金项目
江苏省药学会-天晴医院药学基金科研项目(编号Q202005),南京大学医院管理研究所管理项目课题(编号NDYG2020032),江苏省药学会-奥赛康医院药学科研项目(编号A202308) （编号Q202005）
