中国临床药学杂志2024，Vol.33Issue(9)：673-677,5.DOI:10.19577/j.1007-4406.2024.09.006
不同治疗方案对幽门螺旋杆菌感染初次治疗的疗效影响及影响因素分析
Exploration on the treatment of patients with initial treatment of Helicobacter pylori allergic to penicillin
摘要
Abstract
AIM To investigate the effect of different treatment regimens on the initial treatment of Helicobacter pylori infection and analyze the influencing factors.METHODS A total of 3 292 patients with Helicobacter pylori infection were collected from January 2022 to December 2023,and divided into amoxicillin combined clarithromycin group(2 707 patients),furazolidone combined clarithromycin group(261 patients),cefuroxime combined clarithromycin group(150 patients)and levofloxacin combined clarithromycin group(174 patients).Gender,age,treatment regimen and treatment success rate were compared among the 4 groups.RESULTS There was no significant difference in treatment success rate between ofloxacin combined clarithromycin group and amoxicillin combined clarithromycin group(P＞0.05).The treatment success rate in the cefuroxime combined clarithromycin group and furazolidone combined clarithromycin group was lower than that in the amoxicillin combined clarithromycin group(P＜0.05).Age(OR=1.013,95％CI 1.00-1.02,P＜0.01)and treatment regimen(OR=1.268,95％CI 1.11-1.46,P＜0.01)were independent risk factors for bacterial eradication.CONCLUSION Levofloxacin combined clarithromycin regimen demonstrates a higher success rate of eradication in some patients with initial treatment for Helicobacter pylori infection,and can be used for penicillin-allergic patients with initial treatment for Helicobacter pylori infection.Both age and treatment regimen influence the success rate of treatment in patients with initial treatment for Helicobacter pylori infection.关键词
幽门螺旋杆菌/阿莫西林/青霉素过敏/左氧氟沙星Key words
Helicobacter pylori/amoxicillin/penicillin allergy/levofloxacin引用本文复制引用
袁菁菁,罗孟钊,周锋..不同治疗方案对幽门螺旋杆菌感染初次治疗的疗效影响及影响因素分析[J].中国临床药学杂志,2024,33(9):673-677,5.基金项目
浙江省医药卫生科技计划临床研究应用项目(编号2022KY013) （编号2022KY013）
