中国临床药学杂志2024，Vol.33Issue(9)：682-686,5.DOI:10.19577/j.1007-4406.2024.09.008
阿立哌唑联合丙戊酸镁对双相情感障碍抑郁发作的疗效及安全性分析
Efficacy and safety analysis of aripiprazole combined with magnesium valproate in treating depressive episodes of bipolar disorder
摘要
Abstract
AIM To investigate the efficacy and safety of aripiprazole combined with magnesium valproate in treating depressive episodes of bipolar disorder(BP).METHODS A total of 90 patients with depressive episodes of BP admitted from May 2021 to May 2023 were included in the study and further randomly divided into control group(45 patients,magnesium valproate extended-release tablets)and observation group(45 patients,magnesium valproate extended-release tablets combined with aripiprazole tablets).Treatment outcomes,Hamilton depression rating scale 17(HAMD-17)scores,brain-derived neurotrophic factor,serum inflammatory factors,and adverse reactions between 2 groups of patients were compared.RESULTS The overall clinical effective rate of the observed group(95.56％)was greater than the reference group(62.22％),with a significant difference(P＜0.05).HAMD-17 scores of both groups of patients decreased,and the observation group was lower than the control group after treatment(P＜0.05).Levels of interleukin-4,interleukin-10,brain-derived neurotrophic factor,and transforming growth factor β1 were significantly increased in both groups of patients,and the observation group was higher than the control group.While levels of interleukin-1 and tumor necrosis factor were significantly decreased,and the observation group was better than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between 2 groups(P＞0.05).CONCLUSION Aripiprazole combined with magnesium valproate could enhance treatment outcomes for bipolar depression,alleviate depressive symptoms,reduce inflammation,bolster immune function,and modulate nerve growth factor levels,with a good safety profile.The combination regimen is worthy of clinical promotion.关键词
阿立哌唑/丙戊酸镁/双相情感障碍抑郁发作/疗效/安全性Key words
aripiprazole/magnesium valproate/depressive episodes of bipolar disorder/efficacy/safety引用本文复制引用
薛林峰,曹满占,张宇..阿立哌唑联合丙戊酸镁对双相情感障碍抑郁发作的疗效及安全性分析[J].中国临床药学杂志,2024,33(9):682-686,5.基金项目
河北省2023年度医学科学研究课题计划(编号20232191) （编号20232191）
