氨基葡萄糖联合非甾体抗炎药对膝关节骨性关节炎患者血清炎症因子及骨保护素水平的影响OA

Objective To explore the effects of glucosamine combined with non-steroidal anti-inflammatory drugs(NSAIDs)on serum inflammatory factors and osteoprotectin(OPG)levels in patients with knee osteoarthritis(KOA).Methods A total of 120 KOA patients admitted to Ezhou Egang Hospital from January to March 2023 were selected as the study objects and divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with NSAIDs,and the observation group was treated with glucosamine on the basis of control group.Knee pain severity(visual analogue scale(VAS)score),function(Western Ontario and McMaster University Osteoarthritis Index(WOMAC)score),adverse reactions,serum inflammatory factors(interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6))and OPG level changes were compared between the two groups.Results VAS and WOMAC scores of the two groups were decreased after treatment,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,the serum levels of IL-1β,TNF-α and IL-6 in 2 groups were decreased,the observation group was lower than the control group,and the serum OPG level in 2 groups was increased,the observation group was higher than the control group,the difference was statistically significant(P＜0.05).The incidence of adverse reactions in observation group(10.00%)was significantly lower than that in control group(25.00%),and the difference was statistically significant(P＜0.05).Conclusion In the treatment of KOA patients,glucosamine combined with NSAIDs can effectively reduce the degree of pain,improve knee joint function,reduce the level of serum inflammatory factors,increase the level of serum OPG,which is conducive to the protection of articular cartilage with high safety.