典型抗菌药物在不同品种肉鸡羽毛和皮脂中的残留规律研究OA

[Objective]To explore the residual laws of typical antibacterial drugs in the feather and sebum of different broiler breeds,and eval-uate the significance of feathers in monitoring the veterinary drug residues of broilers.[Method]Xueshan Chicken and AA broilers were fed with flufenicol or enrofloxacin for 21 days before slaughter,and drug residues in the feather and sebum at different time after withdrawal were determined.[Result]The residues of flufenicol and its metabolites(flufenicolamide)in the feathers of the two broiler breeds reached the highest level on the first day after drug withdrawal,and the contents were close.The total residue of enrofloxacin and its metabolites(ciprofloxacin)in the feathers of Xueshan Chicken reached its peak on the first day after withdrawal,and that in AA chicken reached its peak on the third day af-ter withdrawal.The peak residual amount of drugs in the feather of Xueshan Chicken was greatly higher than that in AA broilers.Then the drug residual amount in the feather gradually decreased.On the 14th day after withdrawal,the residues of flufenicol and its metabolites in the the feathers of AA broilers and Xueshan Chicken were 281.37 and 424.30 μg/kg respectively,the content of enrofloxacin and its metabolites were 16.03 and 26.21 μg/kg,respectively.The residual laws of the two drug es in the sebum were similar to those in the feathers,suggesting that mo-nitoring drug residues in the feathers could indirectly infer drug residues in edible tissues.[Conclusion]There were differences in the metabo-lism of the same drug in the feathers of different breeds of broilers,and the drug residues in the feathers could be used as the reference for mo-nitoring the drug residues in broiler products.