北京中医药大学学报2024，Vol.47Issue(11)：1495-1500,6.DOI:10.3969/j.issn.1006-2157.2024.11.003
基于成纤维细胞介导阴茎勃起机制探讨活血化瘀法对勃起功能障碍潜在的治疗作用
Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection
摘要
Abstract
Erectile dysfunction has a high incidence rate and is a difficult-to-treat condition in male urology.The synergistic effect of nerves,endothelium,and smooth muscles plays a crucial role in penile erection.However,the role of the many fibroblasts in the corpus cavernosum of the penis during erection is often overlooked.Fibroblasts are at the center of the cellular and molecular network in the corpus cavernosum of the penis,regulating the dynamic balance of the cavernosal microenvironment and mediating penile erection,thus providing a novel target for treating erectile dysfunction.Blood stasis primarily causes erectile dysfunction,thereby serving as a crucial pathological factor leading to the imbalance of the cavernosal microenvironment.Blood stasis also corresponds to the microscopic pathological changes in the corpus cavernosum of patients with erectile dysfunction.Therefore,this study explored the correlation between fibroblast-mediated penile erection and traditional Chinese medicine theories,integrating it with clinical practice.This study proposes that activating blood and resolving stasis can regulate the cavernosal microenvironment and improve fibroblast-mediated erectile dysfunction.This study also provides novel insights for treating erectile dysfunction with traditional Chinese medicine.关键词
勃起功能障碍/成纤维细胞/海绵体微环境/活血化瘀Key words
erectile dysfunction/fibroblasts/cavernosal microenvironment/activating blood and resolving stasis分类
医药卫生引用本文复制引用
张思政,曹䶮,罗成龙,程皓洋,张琪,焦拥政..基于成纤维细胞介导阴茎勃起机制探讨活血化瘀法对勃起功能障碍潜在的治疗作用[J].北京中医药大学学报,2024,47(11):1495-1500,6.基金项目
国家自然科学基金项目(No.82074446) （No.82074446）
中国中医科学院科技创新工程项目(No.C12021A02202) National Natural Science Foundation of China(No.82074446) （No.C12021A02202）
