福建农业科技2024，Vol.55Issue(9)：30-35,6.DOI:10.13651/j.cnki.fjnykj.2024.09.006
辅酶Q0增强氨基糖苷类和喹诺酮类抗生素杀灭大肠杆菌的效果分析
Analysis on the Enhancement of Aminoglycoside and Quinolone Antibiotics' Effect on Killing Escherichia Coli by Coenzyme Q0
摘要
Abstract
Finding the new-type antibiotic adjuvant to improve the bactericidal efficiency of the existing antibiotics and achieve the rapid and efficient killing of pathogens is an important means to reduce the risk of bacterial resistance.The bactericidal effect of coenzyme Q0(CoQ0)combined with aminoglycosides or quinolones antibiotics against Escherichia coli was tested by adding the exogenous coenzyme Q0.The results showed that the coenzyme Q0 could significantly enhance the bactericidal effect of aminoglycosides and quinolones antibiotics against Escherichia coli BW25113 and 8 strains of clinical drug-resistant Escherichia coli.The results of concentration gradient test and time-dependent test showed that the coenzyme Q0 enhanced the bactericidal activity of aminoglycosides and quinolones antibiotics in a concentration-dependent and time-dependent manner.The optimal concentration of coenzyme Q0 was 30 µg·mL-1.The optimal action time of coenzyme Q0 assisted gentamicin was 5 h,and the optimal action time of coenzyme Q0 assisted ofloxacin was 8 h.The results provided data support for the development of coenzyme Q0 as a new-type adjuvant for aminoglycoside or quinolones antibiotics.关键词
辅酶Q0/氨基糖苷类/喹诺酮类/抗生素/细菌耐药/大肠杆菌Key words
Coenzyme Q0/Aminoglycosides/Quinolones/Antibiotic/Bacterial resistance/Escherichia coli分类
农业科技引用本文复制引用
李映红,李嘉宸霃,王子涵,赵航宇,陈雅娟..辅酶Q0增强氨基糖苷类和喹诺酮类抗生素杀灭大肠杆菌的效果分析[J].福建农业科技,2024,55(9):30-35,6.基金项目
福建省自然科学基金面上项目(2024J01457). （2024J01457）
