风湿病与关节炎2024，Vol.13Issue(11)：7-13,7.DOI:10.3969/j.issn.2095-4174.2024.11.002
骨关节炎与动脉粥样硬化的双向因果风险关系
The Two-way Causal Risk Relationship Between Osteoarthritis and Atherosclerosis
摘要
Abstract
Objective:To explore the two-way causal risk relationship between osteoarthritis and atherosclerosis.Methods:In the open genome-wide association research data platform,the data of single joint or multi joint osteoarthritis and atherosclerosis were collected and analyzed,and the strongly related single nucleotide polymorphisms were screened as instrumental variables for Mendelian randomization analysis(MR).Among them,the inverse variance weighting method was used as the main analysis method,and the weighted median method and MR-Egger method are used to ensure the stability of the results.Results:MR analysis revealed that there was no risk effect relationship between gene predicted osteoarthritis and the increase of atherosclerosis(inverse variance weighted method P>0.05),and inverse MR also suggested that there was no risk relationship between the two(inverse variance weighted method P>0.05).The sensitivity analysis results also supported the above contents.Conclusion:The evidence of MR analysis shows that there is no significant causal relationship between osteoarthritis and atherosclerosis.This contradicts the correlations reported in some previous observational studies,suggesting that these correlations may be composed of other confounding factors.At the same time,this provides genetic evidence for the conclusions of other observational research reports,that is,osteoarthritis does not affect the risk of atherosclerosis,and vice versa.关键词
骨关节炎/动脉粥样硬化/双向因果关系/孟德尔随机化Key words
osteoarthritis/atherosclerosis/two-way causal relationship/Mendelian randomization引用本文复制引用
冀浩然,方柯,周忠云,王萍..骨关节炎与动脉粥样硬化的双向因果风险关系[J].风湿病与关节炎,2024,13(11):7-13,7.基金项目
山东省中医药科技面上项目(M-2023074) （M-2023074）
