风湿病与关节炎2024，Vol.13Issue(11)：14-19,6.DOI:10.3969/j.issn.2095-4174.2024.11.003
系统性红斑狼疮并发股骨头坏死的临床特点及危险因素分析
Analysis of Clinical Characteristics and Risk Factors of Systemic Lupus Erythematosus Complicated with Osteonecrosis of the Femoral Head
摘要
Abstract
Objective:To explore the clinical characteristics and risk factors of patients with systemic lupus erythematosus(SLE)complicated with osteonecrosis of the femoral head(ONFH).Methods:Clinical data of SLE patients treated at Zhengzhou People's Hospital from January 2016 to June 2022 were retrospectively collected.A total of 17 patients with concurrent ONFH were included in the ONFH group,while 51 SLE patients without concurrent ONFH were randomly selected as the control group.The general condition,clinical features,laboratory tests,and treatment status of two groups of SLE patients were compared,and a multivariate analysis was conducted using binary logistics regression.Results:The proportions of fibrinogen>3.5 g·L-1,leukopenia,and positive anti-β2GPⅠ antibodies in the ONFH group were higher than those in the control group(P<0.05);the recurrence rate in the ONFH group(41.18%)was significantly higher than that of the control group(15.69%),but the difference was not statistically significant(P=0.063).Multivariate logistic regression analysis revealed that disease recurrence(OR=4.194,95%CI=[1.053,16.702],P=0.042)and fibrinogen>3.5 g·L-1(OR=9.974,95%CI=[1.457,68.286],P=0.019)are risk factors for SLE complicated with ONFH.Further grouping analysis revealed that among SLE patients with disease recurrence,the proportion of glucocorticoid(GC)treatment time and GC accumulation>10 g were higher than those without recurrence(P<0.05).Conclusion:Disease recurrence and fibrinogen>3.5 g·L-1 are risk factors for ONFH in SLE patients.The increased risk of ONFH in patients with disease recurrence may be related to the increased duration and cumulative amount of GC treatment.关键词
系统性红斑狼疮/股骨头坏死/临床特点/危险因素Key words
systemic lupus erythematosus/osteonecrosis of the femoral head/clinical characteristics/risk factors引用本文复制引用
王旭,高钟丽,桂银莉,常琼洁,陈运转..系统性红斑狼疮并发股骨头坏死的临床特点及危险因素分析[J].风湿病与关节炎,2024,13(11):14-19,6.基金项目
河南省重点研发与推广专项(232102310194) （232102310194）
郑州市医学科研项目(ZZYK2024043) （ZZYK2024043）
