分子影像学杂志2024，Vol.47Issue(11)：1163-1169,7.DOI:10.12122/j.issn.1674-4500.2024.11.02
1.5T磁共振成像可有效监测缺血性脑卒中大鼠模型不同时期的颅脑病变动态
1.5T magnetic resonance imaging can effectively moniter the dynamic changes of cerebral lesions in different stages of ischemic stroke in SD rats
摘要
Abstract
Objective To assess the feasibility and imaging characteristics of clinical 1.5T MRI in visualizing cerebral lesions at different time points(6 h,3 d,5 d,7 d,14 d)in an acute ischemic stroke rat model.Methods Ten healthy male Sprague-Dawley rats,aged 10-12 weeks,were randomly selected and subjected to permanent middle cerebral artery occlusion via the filament method to induce ischemic stroke.MRI scans,including T1WI,T2WI,T2 FLAIR,and DWI,were conducted using a 1.5T clinical MRI scanner at the specified time intervals(6 h,3 d,5 d,7 d,14 d),capturing morphological and signal intensity changes across infarction stages in the rats.Results The DWI sequence obtained from the 1.5T MRI scanner facilitated diagnosis of ultra-acute cerebral infarction in rats,effectively delineating infarction extent and scope.Infarct lesions in the model rats exhibited distinct imaging changes across stages,with signal intensity and morphology alterations becoming apparent in conventional MRI sequences as the infarction progressed.Conclusion The clinical 1.5T MRI technique proves effective in monitoring time-dependent dynamic changes in cerebral lesions in the ischemic stroke rat model.DWI,in particular,exhibits outstanding diagnostic capacity in ultra-acute infarction,thus providing valuable imaging support for advanced clinical research and therapeutic planning.关键词
缺血性脑卒中/临床医用核磁共振/大脑中动脉阻塞大鼠模型/弥散加权成像Key words
ischemic stroke/clinical medical magnetic resonance imaging/rat model of middle cerebral artery occlusion/diffusion weighted imaging引用本文复制引用
李雪琪,索比努尔·亚库甫,唐斌,胡鑫旗,邵华,姜磊..1.5T磁共振成像可有效监测缺血性脑卒中大鼠模型不同时期的颅脑病变动态[J].分子影像学杂志,2024,47(11):1163-1169,7.基金项目
新疆维吾尔自治区科学技术厅中央引导地方科技发展专项资金项目(ZYYD2022A04) （ZYYD2022A04）
