分子影像学杂志2024，Vol.47Issue(11)：1176-1182,7.DOI:10.12122/j.issn.1674-4500.2024.11.04
调节睡眠结构可预防脑小血管病患者基底节区血管周围间隙扩大
Modulation of sleep structure can prevent enlargement of the perivascular spaces in the basal ganglia in patients with cerebral small-vessel disease
摘要
Abstract
Objective To explore the relationship between enlarged perivascular spaces in the basal ganglia(BG-EPVS)and sleep structure in patients with cerebral small-vessel disease(CSVD)by polysomnography.Methods Ninety-five CSVD patients who were hospitalized in the Department of Neurology of the Third Affiliated Hospital of Southern Medical University from February 2023 to June 2024 completed 3.0T magnetic resonance imaging were included.The perivascular spaces in the basal ganglia were evaluated and graded by visual quantitative assessment method,and the patients were divided into none to mild BG-EPVS group(n=45)and moderate to severe BG-EPVS group(n=50)according to the grading.All patients underwent overnight polysomnography monitoring and relevant data were recorded.The general clinical data and polysomnography parameters of the two groups were compared.Results There was no statistically significant difference in gender,BMI,smoking and drinking history between the two groups(P>0.05).Compared with the none to mild BG-EPVS group,patients in the moderate to severe BG-EPVS group were older,and the proportion of lacunar infarction and renal insufficiency was higher(P<0.05).Comparison of sleep parameters between the two groups showed that compared with the none to mild BG-EPVS group,the duration of REM sleep and the percentage of REM sleep in total sleep time were decreased in the moderate to severe BG-EPVS group(P<0.05).There was no statistically significant difference in sleep process parameters,sleep quality parameters and other sleep structure parameters between the two groups(P>0.05).Spearman correlation analysis showed that the duration of REM sleep and the percentage of REM sleep in total sleep time were negatively correlated with the BG-EPVS grade(P<0.05),and there was no significant correlation between the duration and percentage of sleep in NREM sleep stages and the BG-EPVS grade(P>0.05).Multivariate logistic regression analysis found that increased age,lacunar infarction,and decreased percentage of REM sleep in total sleep time were independent risk factors for moderate to severe enlargement of perivascular spaces in the basal ganglia(P<0.05).Conclusion Patients with higher age,lacunar infarction,and decreased percentage of REM sleep in total sleep time are more likely to develop BG-EPVS,suggesting that adjusting sleep structure,especially improving the quality of REM sleep,may play an important role in preventing BG-EPVS.关键词
脑小血管病/基底节区/血管周围间隙/睡眠结构/胶质淋巴系统Key words
cerebral small-vessel disease/basal ganglia region/perivascular space/sleep structure/glymphatic system引用本文复制引用
封晓韵,夏崇爽,何哲朗,黄添容,王子尹,杨灿洪,李焕敏..调节睡眠结构可预防脑小血管病患者基底节区血管周围间隙扩大[J].分子影像学杂志,2024,47(11):1176-1182,7.基金项目
广东省基础与应用基础研究基金区域联合基金项目(2020A1515110506) （2020A1515110506）
广州市基础研究计划项目(2024A04J4728) （2024A04J4728）
