分子影像学杂志2024，Vol.47Issue(11)：1183-1188,6.DOI:10.12122/j.issn.1674-4500.2024.11.05
失眠患者睡眠障碍特征与丘脑亚区体积关联性的年龄差异:基于MRI成像
Age-related differences in the association between sleep disorder characteristics and thalamic subregion volumes in patients with insomnia:based on MRI
摘要
Abstract
Objective To observe the performance of sleep disorders in insomnia patients of different ages,and to compare the volume differences of thalamic subregions in insomnia patients of all ages based on MRI acquisition of nuclear magnetic data of the brain,and to explore the correlation between sleep disorders and the volume of thalamic subregions.Methods Sixty patients with primary insomnia who attended the Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine from July 2023 to June 2024 were categorized by age into young group(18-44 years old),middle-aged group(45-59 years old),and old-aged group(60-75 years old),20 cases per group.The Pittsburgh sleep quality index was used to assess the sleep quality and degree of insomnia of the patients in each group,and the Siemens 3.0T Prisma magnetic imaging system was used to collect 3D T1 structural image data of the patients,to automatically segment and measure the volumes of the thalamus and six subregions,and to analyze and compare the thalamic subregions of the patients in each group.We analyzed and compared the volume differences of the thalamic subregions in each group of patients,and explored the correlation between the patients'sleep disorders and the volume of the thalamic subregions using partial correlation analysis.Results The Pittsburgh sleep quality index total score,sleep latency,habitual sleep efficiency and insomnia degree grading differed among patients with primary insomnia of different ages(P<0.05),and significant intergroup differences existed among the medial thalamus,lateral thalamus,posterior thalamus and thalamus total volume(P<0.05).Moreover,the results of the partial correlation analysis showed that the sleep efficiency was negatively correlated to the volume of posterior thalamus(r=-0.274,P=0.038).Conclusion Primary insomnia patients of different age groups have different manifestations of sleep disorders.MRI was used to collect brain nuclear magnetic data from insomnia patients,and the analysis of the MRI data revealed that it might be related to the atrophy of grey matter structures in some brain regions of the thalamic system,which provides an important reference for individualized treatment of the patients and improvement of clinical prognosis.关键词
失眠/睡眠障碍/丘脑亚区/年龄/结构MRIKey words
insomnia/sleep disorder/thalamic subregion/age/structural MRI引用本文复制引用
潘星朵,王雅君,李铭,李燕燕,周小燕,张贞,刘传豪,吴垠,林增如..失眠患者睡眠障碍特征与丘脑亚区体积关联性的年龄差异:基于MRI成像[J].分子影像学杂志,2024,47(11):1183-1188,6.基金项目
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023102) （zyyzdxk-2023102）
福建省中青年教师教育科研项目(科技类)(JAT220120) （科技类）
康复学科开放课题(KF2022001) （KF2022001）
面向农村和城市社区推广适宜技术项目(2023TG0101) （2023TG0101）
福建省创伤骨科急救与康复临床医学研究中心项目(2020Y2014) （2020Y2014）
